AI Article Synopsis
- The article outlines a straightforward method for creating C3-perfluoroalkyl-substituted phthalides in a single reaction step.
- The process involves the reaction of 2-cyanobenzaldehyde with (perfluoroalkyl)trimethylsilanes after adding KF or triethylamine.
- This reaction proceeds through nucleophilic addition followed by intramolecular cyclization, resulting in good yields of the desired compound.
Article Abstract
Discribed in this article is a versatile and practical method for the synthesis of C3-perfluoroalkyl-substituted phthalides in a one-pot manner. Upon treatment of KF or triethylamine, 2-cyanobenzaldehyde reacted with (perfluoroalkyl)trimethylsilanes via nucleophilic addition and subsequent intramolecular cyclization to give perfluoroalkylphthalides in good yields.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789380 | PMC |
| http://dx.doi.org/10.3762/bjoc.14.12 | DOI Listing |
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Article Synopsis
- The article outlines a straightforward method for creating C3-perfluoroalkyl-substituted phthalides in a single reaction step.
- The process involves the reaction of 2-cyanobenzaldehyde with (perfluoroalkyl)trimethylsilanes after adding KF or triethylamine.
- This reaction proceeds through nucleophilic addition followed by intramolecular cyclization, resulting in good yields of the desired compound.
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