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Overuse of medical imaging and effects of payer-provider integration: quasi-experimental evidence from Finland.
Health Econ Rev
January 2025
Finnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Background: Healthcare expenditures have risen in middle- and high-income countries. One of the potential contributors is the overuse of diagnostics. I explore whether medical imaging is overused when privately owned clinics in Finland treat patients with voluntary private health insurance (VPHI).
View Article and Find Full Text PDFAnthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome.
Cell Death Discov
January 2025
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome is a rare genetic disorder caused by mutations in the TP63 gene, which encodes a transcription factor essential for epidermal gene expression. A key feature of AEC syndrome is chronic skin erosion, for which no effective treatment currently exists. Our previous studies demonstrated that mutations associated with AEC syndrome lead to p63 protein misfolding and aggregation, exerting a dominant-negative effect.
View Article and Find Full Text PDFEvaluating Spherical Trees in the Urban Environment in Budapest (Hungary).
Plants (Basel)
January 2025
Department of Landscape Protection and Reclamation, Institute of Landscape Architecture, Urban Planning and Garden Art, Hungarian University of Agriculture and Life Sciences, 1118 Budapest, Hungary.
The world's big cities, including Budapest, are becoming more crowded, with more and more people living in smaller and smaller spaces. There is an increasing demand for more green space and trees, with less vertical and less horizontal space. In addition, deteriorating environmental conditions are making it even more difficult for trees to grow and survive.
View Article and Find Full Text PDFThe Effect of Continuous Selection in KiwiCross Composite Breed on Breed Ancestry and Productivity Performance.
Animals (Basel)
January 2025
Animal Science Department, Cornell University, Ithaca, NY 14850, USA.
Composite crosses result from the mating of two or more distinct cattle breeds. Breeding performance may improve rapidly using a well-organized composite breeding system and a clear selection index. The KiwiCross is a popular composite cross in New Zealand, combining Holstein-Friesian (high milk production) and Jersey (high milk fat).
View Article and Find Full Text PDFPhase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies.
Leukemia
January 2025
Department of Medicine; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Article Synopsis
- This study focuses on PRT543, a new oral medication designed to inhibit PRMT5, an enzyme implicated in the growth of certain blood cancers.
- It specifically investigates the effects of PRT543 in patients suffering from advanced myeloid malignancies that have mutations in splicing factors, which are crucial for proper gene expression and can contribute to cancer progression.
- The early Phase Ib trial aims to assess the safety, tolerability, and initial effectiveness of PRT543 in these patients, providing groundwork for potential future treatments.
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