Not only the mean glandular dose (MGD) but also the glandular dose distribution is important in describing the radiation exposure to breast in mammography. For a more precise knowledge of the absorbed dose distribution in the breast, experimental measurements with thermoluminescence dosemeter and Monte Carlo simulations with Geant4 were performed in this study. The experimental measurements with homogeneous physical breast phantoms were used to validate Monte Carlo simulations of homogeneous mathematical breast models undergoing mammography. Then a 3D detailed breast model with a compressed breast thickness of 4 cm and a glandular content of 50%, which has been constructed in previous work, was used to study the absorbed dose distribution inside the breast undergoing mammography. Furthermore, the effects of the glandular tissue distribution on MGD were studied by reversing the breast model in head-toe direction to get a breast model with a different distribution of glandular tissues.
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http://dx.doi.org/10.1093/rpd/ncy017 | DOI Listing |
Arch Pharm (Weinheim)
January 2025
European Institute for Molecular Imaging (EIMI), University of Muenster, Muenster, Germany.
The P2X4 receptor (P2X4R), a ligand-gated ion channel activated by ATP, plays a critical role in neuroinflammation, chronic pain, and cancer progression, making it a promising therapeutic target. In this study, we explored the design and synthesis of piperazine-based P2X4R antagonists, building on the structural framework of paroxetine. A series of over 35 compounds were synthesized to investigate structure-activity relationships (SARs) in a Ca²⁺-flux assay for P2X4R antagonistic activity.
View Article and Find Full Text PDFBMC Cancer
December 2024
ISTCT UMR 6030-CNRS, Université de Caen-Normandie, Caen, 14000, France.
Background: Proton therapy (PRT) is an innovative radiotherapeutic modality for the treatment of cancer with unique ballistic properties. The depth-dose distribution of a proton beam reduces exposure of healthy tissues to radiations, compared with photon-therapy (XRT). To date, only few indications for proton-therapy, like pediatric cancers, chordomas, or intra-ocular neoplasms, are reimbursed by Health systems.
View Article and Find Full Text PDFClin Ther
December 2024
Department of Infectious Diseases, CHU Clermont-Ferrand, Clermont-Ferrand, France. Electronic address:
Purpose: High doses of amoxicillin are recommended to treat severe infections such as endocarditis. Amoxicillin causes dose-dependent toxicities, in particular crystal nephropathy. Toxicity could be avoided by monitoring of amoxicillin trough plasma concentrations (ATPC).
View Article and Find Full Text PDFEnviron Res
December 2024
Department of Global Smart City & School of Civil, Architectural Engineering, and Landscape Architecture, Sungkyunkwan University, 2066 Seobu-ro, Suwon 16419, Republic of Korea. Electronic address:
Titanium dioxide (TiO) is the most commonly used catalyst for fabricating commercial photocatalytic air purifier (AP) systems. The AP performance can be affected sensitively by the preparation conditions of filters and the physicochemical properties (e.g.
View Article and Find Full Text PDFRadiol Phys Technol
December 2024
Nucleaer Science and Engineering Center, Japan Atomic Energy Agency, 2-4 Shirakata, Tokai-Mura, Ibaraki, 319-1195, Japan.
One radiation protection measure for medical personnel in X-ray fluoroscopy is using radiation protective plates. A real-time interactive tool visualizing radiation-dose distribution varied with the protective plate position will help greatly to train medical personnel to protect themselves from unnecessary radiation exposure. Monte Carlo simulation can calculate the individual interactions between radiations and objects in the X-ray room, and reproduce the complex dose distribution inside the room.
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