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| http://dx.doi.org/10.1161/CIRCEP.118.006137 | DOI Listing |
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In silico analysis of ventricular action potential with a current-voltage-time representation: Thresholds, membrane resistance, repolarization reserve.
Physiol Rep
November 2024
Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma (Italy) - Parco Area Delle Scienze, Parma, Italy.
The waveform of ventricular action potential (AP) is a key determinant of the cardiac cycle, a marker of beating pathophysiology, and a target for anti-arrhythmic drug design. The information contained in the waveform, though, is limited to the actual dynamics of the AP under consideration. By measuring quasi-instantaneous current-voltage relationships during repolarization, I propose a three-dimensional representation of the ventricular AP which includes potential dynamic responses that the beat can show when electrically perturbed.
View Article and Find Full Text PDFObjective: The pathophysiological role of the small conductance calcium-activated potassium (SK) channels in human ventricular myocytes remains unclear. Experimental studies have reported upregulation of in pathological states, potentially contributing to ventricular arrhythmias. In heart failure (HF) patients, the upregulation of SK channels could be an adaptive physiological response to shorten the action potential duration (APD) under conditions of reduced repolarization reserve.
View Article and Find Full Text PDFConnecting transcriptomics with computational modeling to reveal developmental adaptations in pediatric human atrial tissue.
Am J Physiol Heart Circ Physiol
December 2024
Children's National Heart Institute, Children's National Hospital, Washington, District of Columbia, United States.
Nearly 1% of babies are born with congenital heart disease-many of whom will require heart surgery within the first few years of life. A detailed understanding of cardiac maturation can help to expand our knowledge on cardiac diseases that develop during gestation, identify age-appropriate drug therapies, and inform clinical care decisions related to surgical repair and postoperative management. Yet, to date, our knowledge of the temporal changes that cardiomyocytes undergo during postnatal development is limited.
View Article and Find Full Text PDFAdditive Inhibition of HERG Channels Expressed in Xenopus Oocytes by Antipsychotic Drugs and Citrus Juice Flavonoid Naringenin.
Pharmacology
September 2024
Department of Pharmacology and Therapeutics, College of Pharmacy, Kuwait University, Kuwait City, Kuwait.
Introduction: Citrus juice has been shown to cause QT prolongation in electrocardiograms of healthy volunteers, and naringenin, a major flavonoid found in citrus juice, has been identified as the potent inhibitor of human ether-a-go-go-related gene (HERG) channels as the cause of QT prolongation. Inhibition of HERG channels and prolongation of QT interval by antipsychotic drugs such as haloperidol, chlorpromazine, and clozapine have also been shown. However, naringenin's effect on HERG channel function in conjunction with antipsychotic medications has not been investigated.
View Article and Find Full Text PDFβ-Adrenoceptor blockade can augment the torsadogenic action of risperidone.
J Pharmacol Sci
October 2024
Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. Electronic address:
Article Synopsis
- Risperidone is a second-generation antipsychotic used for schizophrenia and bipolar disorder, but it has a conditional risk for causing torsade de pointes (TdP), a serious heart arrhythmia.
- Research on dogs with chronic atrioventricular block showed that while risperidone alone did not induce TdP, combining it with the β-adrenoceptor blocker atenolol increased the risk significantly.
- The study suggests that using β-adrenoceptor blockers with risperidone can lower the heart's repolarization reserves, which raises the potential for TdP, highlighting the need for caution in patients with heart-related issues.
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