AI Article Synopsis
- * Researchers identified 515 downregulated and 243 upregulated genes, finding that the upregulated genes were linked to immune responses, while the downregulated genes were tied to cell adhesion and muscle contraction.
- * Key genes identified in the protein-protein interaction analysis, such as ITGAM and ACTN2, suggest that disruptions in immune regulation and smooth muscle cell function contribute to the worsening of carotid atherosclerosis, potentially guiding future treatments.
Article Abstract
The present study aimed to examine the universal gene expression signature and the underlying molecular mechanisms involved in the progression of carotid atherosclerotic plaques. The gene expression dataset, GSE28829, containing 13 early and 16 advanced carotid atherosclerotic plaques was selected for analysis. The differentially expressed genes (DEGs) were identified and analyzed using bioinformatics analyses, including cluster analysis, Gene Ontology (GO) and pathway enrichment analyses. Finally, a protein‑protein interaction (PPI) was constructed and analyzed. A total of 515 downregulated and 243 downregulated DEGs were identified. The cluster analysis revealed two separate two groups. In addition, the GO terms enriched by the upregulated DEGs were associated with immune response, and the downregulated DEGs were associated with cell adhesion. The upregulated DEGs were enriched in pathways associated with signaling in the immune system, and the downregulated DEGs were enriched in pathways associated with muscle contraction. In the PPI network analysis, ITGAM and ACTN2 had the highest decrees of connectivity in the upregulated and downregulated DEGs, respectively. These findings suggested that deregulation of the immune system and smooth muscle cell cytoskeleton accelerates the progression of carotid atherosclerotic plaques. The DEGs identified may offer potential in the prevention and treatment of atherosclerosis in the carotid artery.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866022 | PMC |
| http://dx.doi.org/10.3892/mmr.2018.8575 | DOI Listing |
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