Background And Aims: We devised a technique to treat peripheral arterial disease (PAD) with laser, i.e. percutaneous transluminal laser angioplasty (PTLA). Considerable good results were obtained with PTLA, but it is apparently considered obsolete as a technique to treat occlusive arterial disease of peripheral arteries, perhaps because of the development and improvement of stents and the ease of their use compared to the somewhat intricate technique required for PTLA. Although the author admits the usefulness of stents, they are foreign to a human body. PTLA does not use a foreign body and contributes to the regeneration of the body's own artery.The aim of this article is to elucidate the beneficial effects of laser procedures in the treatment of PAD and to show the resulting good long-term patency, and to propose PTLA as an option to treat PAD.Some basic experiments and their results useful for PTLA will be introduced.

Materials And Methods: Ninety cases with occlusive peripheral arterial diseases were treated with PTLA during the period of March 1985 to March 1991.Our method of PTLA consists of occlusion of the proximal artery by a dilated balloon of a percutaneously introduced balloon catheter, and flushing with normal saline during irradiation by Nd:YAG laser.We used a ceramic tip attached to a laser catheter most of the time and a bare laser fiber under angioscopy or a bare laser fiber itself to treat smaller arteries in the legs.

Results: The initial success rate was 90%.The patency rates of PAD at 6 years are 91.4% (iliac artery) and 85.8% (femoropopliteal artery), and the patency rate of leg artery lesions is 100% at 5 years.Some clinical cases with long-term patency (6 and 30 years) will be introduced.Some fundamental experiments useful to the application of laser to atheroma or thrombi will be introduced.

Conclusions: PTLA could be a useful option to treat occlusive PAD, because it can produce longterm patency of natural arteries, provided a proper lesion was selected.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801451PMC
http://dx.doi.org/10.5978/islsm.17-RE-01DOI Listing

Publication Analysis

Top Keywords

ptla
9
percutaneous transluminal
8
laser
8
transluminal laser
8
laser angioplasty
8
technique treat
8
peripheral arterial
8
arterial disease
8
treat occlusive
8
long-term patency
8

Similar Publications

The oxidative pentose phosphate pathway (OPPP) plays an important role for the generation of reducing power in all eukaryotes. In plant cells the OPPP operates in several cellular compartments, but as full cycle only in the plastid stroma where it is essential. As suggested by our recent results, OPPP reactions are also mandatory inside peroxisomes, at least during fertilisation.

View Article and Find Full Text PDF

Background: LDBio immunochromatographic lateral flow assay, a point-of care test, detects IgM/IgG antibodies against Aspergillus fumigatus (LDBio-ALFA). LDBio-ALFA has been evaluated for diagnosing chronic pulmonary aspergillosis (CPA) in hospital patients, though its efficacy in field settings remains unexamined.

Objective: Our primary objective was to assess the diagnostic accuracy of LDBio-ALFA in diagnosing CPA in a field and a hospital cohort.

View Article and Find Full Text PDF

The development of clean energy solutions, such as fuel cells and hydrogen energy, is crucial for addressing the global energy shortage. Platinum (Pt)-based catalysts are widely used in fuel cells and hydrogen energy generation (for example, via water electrolysis). However, reducing the amount of Pt used while maintaining the catalytic performance of such catalysts is essential.

View Article and Find Full Text PDF

Many chemotherapies, which are still the main clinical treatment for primary tumors, will induce persistent DNA damage in non-tumor stromal cells, especially cancer-associated fibroblasts (CAFs), and activate them to secrete senescence-associated secretory phenotype (SASP). The transition could further result in the formation of tumor immunosuppressive microenvironment and cause drug resistance of neighboring tumor cells. To solve this dilemma, a multi-functional biomimetic drug delivery system (named mPtP@Lipo) was rationally developed by combining CAFs reshaper ginsenoside 20(S)-protopanaxadiol (PPD) and cisplatin prodrug (PtLA) to inhibit tumor progression and the formation of SASP.

View Article and Find Full Text PDF

Background: Post-tuberculosis lung abnormality (PTLA) is the most common risk factor for chronic pulmonary aspergillosis (CPA), and 14%-25% of the subjects with PTLA develop CPA. The pathogenesis and the host immune response in subjects with PTLA who develop CPA need to be better understood.

Methods: We prospectively compared the innate and adaptive immune responses mounted by patients of PTLA with or without CPA (controls).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!