Increased gliosis has been previously described in schizophrenic brain. In this study, the degree of gliosis in schizophrenic and control brains was assessed quantitatively using an antibody to glial fibrillary acidic protein, immunocytochemical techniques, and a computed image analysis system. Twenty separate brain areas were assessed, and no significant differences were found between the schizophrenic and control groups. It seems unlikely that a specific pattern of pathologically significant gliosis is present in schizophrenic brains. These negative findings are of note because of previously reported structural differences in the temporal lobe in the schizophrenic group in this series.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0006-3223(86)90285-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Memantine Rescues Neurosyphilis-Related Schizophrenic-like Features and Cognitive Deficit.
Clin Neuropharmacol
February 2020
Department of Psychiatry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City.
Objectives: Neurosyphilis, an infectious neuroinflammatory disorder, could cause diverse neuropsychiatric symptoms mimicking disorders of schizophrenia and dementia; hence, it is known as the "chameleon of psychiatry." Here, we present a subject with neurosyphilis with schizophrenic features and share the treatment outcome.
Methods: A 42-year-old single man had schizophrenic-like features and cognitive dysfunction for 1 year.
Purkinje cells pathology in schizophrenia. A morphometric approach.
Rom J Morphol Embryol
April 2018
Laboratory of Neuropathology and Electron Microscopy, AHEPA Hospital, Thessaloniki, Greece;
Objectives: Schizophrenia is a brain disorder that affects more than 21 million people worldwide. Ventricle enlargement and reduction in the volume of the temporal lobe overall and in medial temporal structures constitutes the main macroscopic findings, whilst synaptic and spinal changes as well as gliosis in the hippocampal formation, the prefrontal and the entorhinal cortex stand among cardinal microscopic findings in the schizophrenic brains. In recent years, accumulated evidence comes to light about the role of cerebellum in the pathophysiology of schizophrenia.
View Article and Find Full Text PDFHypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
Brain Imaging Behav
March 2016
Department of Radiology, New York University School of Medicine, 660 First Avenue, New York, NY, 10016, USA.
Working memory (Work-Mem), the capacity to hold and manipulate information, activates the anterior cingulate cortex (ACC), especially its caudal subregion. Impaired Work-Mem and structural and functional abnormalities of the ACC are reported in schizophrenia. This study aims to elucidate the pathogenesis of Work-Mem dysfunction in schizophrenia by comparing metabolite concentrations across ACC subregions.
View Article and Find Full Text PDF[Current conceptions about astrocyte reactivity in schizophrenia].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2014
Literature data of the last two decades are summarized. Based on the classic conceptions about structure and functions of astrocytes, the authors review further development of research concerning the role of astroglia in schizophrenia in the following aspects: astrocyte reactivity, ultrastructural astrocyte pathology, markers of gliosis and astrocyte activation in schizophrenia, effect of neuroleptics on astrocytes. In conclusion, the authors emphasize that current studies confirm the absence of astrogliosis in the brain of schizophrenic patients.
View Article and Find Full Text PDF[Schizophrenia: neurodevelopmental disorder or degenerative brain process?].
Fortschr Neurol Psychiatr
May 2008
Universitäts-Nervenklinik, Bonn, Germany.
In the last two decades schizophrenia is viewed increasingly as a neurodevelopmental (ND) disorder; as indicators are discussed f.e. premorbid personality, behaviour anomalies, premorbid somatic signs, deviations shown by brain imaging methods, neuropathological findings or neuropsychological deficits.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!