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The Effect of Area-Level Deprivation on the Severity of Cubital Tunnel Syndrome on Presentation to a Hand Surgeon.
J Hand Surg Am
December 2024
The Pritzker School of Medicine, The University of Chicago Medical Center, Chicago, IL; Department of Orthopaedic Surgery & Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL.
Purpose: Cubital tunnel syndrome (CuTS) is the second most common upper-extremity neuropathy and can cause debilitating symptoms. Patients presenting to care with severe CuTS can be left with permanent weakness and numbness despite treatment. The aim of this study was to examine the relationship between area-level deprivation and the severity of CuTS on presentation to a hand surgeon.
View Article and Find Full Text PDFEnhancing peptide and PMO delivery to mouse airway epithelia by chemical conjugation with the amphiphilic peptide S10.
Mol Ther Nucleic Acids
September 2024
Feldan Therapeutics, 2666 Boulevard du Parc Technologique Suite 290, Québec, QC G1P 4S6, Canada.
Delivery of antisense oligonucleotides (ASOs) to airway epithelial cells is arduous due to the physiological barriers that protect the lungs and the endosomal entrapment phenomenon, which prevents ASOs from reaching their intracellular targets. Various delivery strategies involving peptide-, lipid-, and polymer-based carriers are being investigated, yet the challenge remains. S10 is a peptide-based delivery agent that enables the intracellular delivery of biomolecules such as GFP, CRISPR-associated nuclease ribonucleoprotein (RNP), base editor RNP, and a fluorescent peptide into lung cells after intranasal or intratracheal administrations to mice, ferrets, and rhesus monkeys.
View Article and Find Full Text PDFUnilateral Compressive Peroneal Neuropathy in Intensive Care Settings During the COVID-19 Pandemic: A Series of Three Cases.
Cureus
July 2024
Department of Rehabilitation Medicine, Faculty of Medicine, Universiti Teknologi MARA (Majlis Amanah Rakyat), Sungai Buloh, MYS.
Peroneal nerve entrapment, typically associated with behaviors like cross-legged sitting or squatting, can also occur from extended periods of lying down where the lower limbs usually assume a position of hip external rotation and knee flexion. In such positions, the fibular head's prominence can exert sustained pressure on the peroneal nerve. We report three cases of unilateral peroneal neuropathy in intensive care unit (ICU) patients during the coronavirus disease (COVID-19) pandemic, highlighting the possible role of prolonged supine or lateral decubitus positions in the development of this condition.
View Article and Find Full Text PDFPeripheral nerve injuries associated with dislocated supracondylar fractures of distal humerus in children: incidence and need of surgical treatment.
Childs Nerv Syst
November 2024
Trauma Center, Department of Pediatric Surgery, National Institute of Children's Diseases, Bratislava, Slovakia.
Purpose: The objective of this study was to determine the incidence, necessity for neurosurgical intervention, and overall results of the treatment of pediatric peripheral nerve injuries associated with dislocated supracondylar fractures of the distal humerus.
Method: A retrospective analysis of pediatric patients with supracondylar fractures treated from April 2019 to April 2022 with a minimum follow-up of 3 months was conducted.
Results: Of 453 included patients, there were 51 recorded peripheral nerve injuries.
Endobronchial coil lung volume reduction performed on patients with emphysema dominant COPD: Long term follow-up results.
Tuberk Toraks
March 2024
Clinic of Pulmonary Diseases, Ankara Etlik State Hospital, Ankara, Türkiye.
Introduction: Chronic obstructive pulmonary disease (COPD) is a commonly seen, preventable, and treatable disease with permanent respiratory symptoms and air entrapment that is caused by particle exposure. In case of limited response to traditional treatment protocols, lung volume reduction may be performed in patients with emphysema dominant patterns. In this study, long term follow-up results of the patients who had been operated on by minimal invasive bronchoscopic lung volume reduction surgery by coil placement were reported.
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