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Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection. | LitMetric

Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection.

Biomed Res Int

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agriculture Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.

Published: August 2018

AI Article Synopsis

  • - Ectromelia virus (ECTV) causes mousepox and serves as a key model for studying how host genetics influence virus-related diseases, showing high mortality in susceptible mouse strains like BALB/c while others like C57BL/6 exhibit resistance.
  • - A microarray analysis comparing spleen tissues from BALB/c and C57BL/6 mice revealed that the susceptible BALB/c mice had a greater number of differentially expressed genes (DEGs), indicating a stronger immune response.
  • - The DEGs in susceptible mice were linked to immune response, metabolism, and cancer pathways, whereas resistant mice had DEGs associated mainly with signaling pathways and cell migration, suggesting different mechanisms at play in the host response to ECTV.

Article Abstract

Ectromelia virus (ECTV), the causative agent of mousepox, has emerged as a valuable model for investigating the host- relationship as it relates to pathogenesis and the immune response. ECTV is a mouse-specific virus and causes high mortality in susceptible mice strains, including BALB/c and C3H, whereas C57BL/6 and 129 strains are resistant to the disease. To understand the host genetic factors in different mouse strains during the ECTV infection, we carried out a microarray analysis of spleen tissues derived from BALB/c and C57BL/6 mice, respectively, at 3 and 10 days after ECTV infection. Differential Expression of Genes (DEGs) analyses revealed distinct differences in the gene profiles of susceptible and resistant mice. The susceptible BALB/c mice generated more DEGs than the resistant C57BL/6 mice. Additionally, gene ontology and KEGG pathway analysis showed the DEGs of susceptible mice were involved in innate immunity, apoptosis, metabolism, and cancer-related pathways, while the DEGs of resistant mice were largely involved in MAPK signaling and leukocyte transendothelial migration. Furthermore, the BALB/c mice showed a strong induction of interferon-induced genes, which, however, were weaker in the C57BL/6 mice. Collectively, the differential transcriptome profiles of susceptible and resistant mouse strains with ECTV infection will be crucial for further uncovering the molecular mechanisms of the host- interaction.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752998PMC
http://dx.doi.org/10.1155/2017/6456180DOI Listing

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