Tetraspanin blockage reduces exosome-mediated HIV-1 entry. | LitMetric

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Tetraspanin blockage reduces exosome-mediated HIV-1 entry. | LitMetric

Tetraspanin blockage reduces exosome-mediated HIV-1 entry.

Brian Sims Anitra L Farrow Sparkle D Williams Anju Bansal Alexandre Krendelchtchikov Qiana L Matthews

Arch Virol

Center for AIDS Research, University of Alabama at Birmingham, Birmingham, USA.

Published: June 2018

- HIV-1 is a widely researched retrovirus with significant implications for health.
- Researchers are starting to understand how exosomes, small vesicles released by cells, are involved in the entry and development of HIV-1.
- Exosomes can carry host proteins, like tetraspanins, which are also found in viruses, suggesting a potential link between them and viral behavior.

HIV-1 is one of the most studied retroviruses. The role of exosomes in HIV-1 entry and pathogenesis are beginning to be appreciated. Exosomes can incorporate host proteins that are also contained in viruses (e.g., tetraspanins).

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958159	PMC
http://dx.doi.org/10.1007/s00705-018-3737-6	DOI Listing

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