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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878216 | PMC |
| http://dx.doi.org/10.1113/JP275924 | DOI Listing |
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Unraveling the Mechanism of Impaired Osteogenic Differentiation in Osteoporosis: Insights from Gene Polymorphism.
Cells
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Laboratory of Molecular Science, Institute of Cytology, Russian Academy of Sciences, Saint Petersburg 194064, Russia.
Osteoporosis is characterized by increased resorption and decreased bone formation; it is predominantly influenced by genetic factors. G-protein coupled receptors (GPCRs) play a vital role in bone homeostasis, and mutations in these genes are associated with osteoporosis. This study aimed to investigate the impact of single nucleotide polymorphism (SNP) rs1042713 in the gene, encoding the beta-2-adrenergic receptor, on osteoblastogenesis.
View Article and Find Full Text PDFManagement of T cell responses by anesthetic drugs-propofol & isoflurane in perioperative breast cancer patients: A prospective hospital-based study.
Indian J Med Res
November 2024
Department of Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, Kolkata, India.
Background & objectives The choice of anesthetic for better perioperative conservation of immune responses has always been contentious. This study investigated the differential impact of the intravenous anesthetic, propofol, and the volatile anesthetic, isoflurane on the T cell immune responses, if any, among individuals going through perioperative breast cancer. Methods Perioperative blood samples (preoperative, intraoperative and postoperative) collected from participants with breast cancer in two arms namely isoflurane arm (n=50) and the propofol arm (n=50) were analyzed for T cell immune response using flow cytometry and ELISA.
View Article and Find Full Text PDFMethylcellulose enhances resolution in gravitational field-flow fractionation: Going beyond viscosity.
J Chromatogr A
January 2025
Department "Area Materno-Infantile" Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan Italy.
Gravitational Field-Flow Fractionation (GrFFF) is an elution-based method designed for the separation of particles ranging from a few micrometers up to approximately 100 μm in diameter. Separation occurs over time, with particles being fractionated based on size and other physico-chemical properties. GrFFF takes advantage of gravitational forces acting perpendicularly to a laminar flow in a thin channel.
View Article and Find Full Text PDFEmergent salvage of the vertebral artery with flow diverter pipeline stent following vessel laceration: Systematic literature review and illustrative case example.
Surg Neurol Int
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Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma, United States.
Background: Iatrogenic injury to neck vasculature is a potentially life-threatening complication of spine surgery. We present an illustrative case describing the use of the Pipeline Embolization Device (PED) in the emergent reconstruction of the vertebral artery (VA) following vessel laceration. In addition, we document a systematic review concerning the use of the PED in acute to chronic iatrogenic injury of the internal carotid or VAs.
View Article and Find Full Text PDFPercutaneous Screw Fixation of Proximal Fifth Metatarsal Fractures.
JBJS Essent Surg Tech
November 2024
Department of Orthopaedics Foot and Ankle Surgery, The Ohio State University, Columbus, Ohio.
Article Synopsis
- Metatarsal fractures, particularly affecting the fifth metatarsal, are common injuries, making up 5-6% of outpatient fractures, with zone 2 fractures—specifically Jones fractures—being difficult to manage due to poor blood supply and higher nonunion rates.
- Surgical treatment, particularly open reduction and internal fixation (ORIF), is preferred for Jones fractures, as it leads to better healing rates compared to conservative treatment methods.
- The surgical technique involves careful anatomical marking and using a guidewire for screw placement to compress the fracture, followed by a recovery period that includes non-weight-bearing and gradual weight-bearing activities.*
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