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Non-traditional risk factors for atrial fibrillation: epidemiology, mechanisms, and strategies.
Eur Heart J
December 2024
Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.
Atrial fibrillation (AF) has become the pre-dominant arrhythmia worldwide and is associated with high morbidity and mortality. Its pathogenesis is intricately linked to the deleterious impact of cardiovascular risk factors, emphasizing the pivotal imperative for early detection and mitigation strategies targeting these factors for the prevention of primary AF. While traditional risk factors are well recognized, an increasing number of novel risk factors have been identified in recent decades.
View Article and Find Full Text PDFTrimethylamine N-oxide in cardiovascular disease: Pathophysiology and the potential role of statins.
Life Sci
January 2025
Department of Internal Medicine, Metropolitan Hospital Center, New York, NY, USA. Electronic address:
Cardiovascular diseases are one of the leading causes of mortality and morbidity worldwide, with the total number of cases increasing to 523 million in 2019. Despite the advent of new drugs, cardiovascular mortality has increased at an alarming rate of 53.7 % from 12.
View Article and Find Full Text PDFThe Causal Relationship between Gut Microbiota and Atrial Fibrillation: A Two-Sample Mendelian Randomization Study.
Arq Bras Cardiol
December 2024
Department of Cardiology, The First People's Hospital of Hefei, The Third Affiliated Hospital of Anhui Medical University, Hefei - China.
Background: Previous studies have adequately characterized the gut microbiota (GM) in atrial fibrillation (AF). Nevertheless, the precise causality between GM and AF remains elusive.
Objectives: This study utilized public data from genome-wide association studies to explore the causality between GM and AF.
Integrative approaches to atrial fibrillation prevention and management: Leveraging gut health for improved cardiovascular outcomes in the aging population.
Curr Probl Cardiol
December 2024
Department of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Article Synopsis
- Atrial fibrillation (AF) is a common heart condition linked to serious complications like stroke and heart failure, and recent studies suggest that an imbalance in gut bacteria may play a significant role, especially in older adults.
- The review explores how gut microbiota and their byproducts might trigger AF and stresses the need for more research on the connection between gut health and heart function, which is often overlooked.
- Future studies should focus on the gut microbiome's impact on AF and consider using probiotics or prebiotics as part of treatment, potentially leading to innovative ways to improve patient care by connecting heart and gut health.
Gut Microbe-Generated Metabolite Trimethylamine-N-Oxide and Ischemic Stroke.
Biomolecules
November 2024
Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, China.
Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite, the production of which in vivo is mainly regulated by dietary choices, gut microbiota, and the hepatic enzyme flavin monooxygenase (FMO), while its elimination occurs via the kidneys. The TMAO level is positively correlated with the risk of developing cardiovascular diseases. Recent studies have found that TMAO plays an important role in the development of ischemic stroke.
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