The incidence of intraductal papillary mucinous neoplasms (IPMNs) has been increasing over the past decade, mainly owing to increased awareness and the increased use of cross-sectional imaging. The Sendai and Fukuoka consensus guidelines provide us with clinical management guidelines and algorithms; however, the clinical management of IPMNs continues to be challenging. Our incomplete understanding of the natural history of the disease, and the events and pathways that permit progression to adenocarcinoma, result in difficulties predicting which tumors are high risk and will progress to invasive disease. In this review, we summarize the current management guidelines and describe ongoing efforts to more clearly stratify IPMNs by risk of malignancy and identify IPMNs with malignant potential or ongoing malignant transformation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808987 | PMC |
| http://dx.doi.org/10.1097/MPA.0000000000000999 | DOI Listing |
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Article Synopsis
- The study assesses the risk associated with sub-centimeter Side-Branch Intraductal Papillary Mucinous Neoplasms (SB-IPMN) to inform a surveillance strategy.
- Sub-centimeter SB-IPMNs show a lower rate of clinically relevant progression compared to larger cysts, although they can still develop high-risk pathologies over time.
- The findings suggest that size growth alone is not a reliable indicator of malignant potential, emphasizing the need for careful monitoring regardless of cyst size.
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