Decrease in expression caused by infection may promote progression to severe gastritis.

SNP rs2294008 in () and decreased expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of -infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis ( 9.4 × 10; odds ratio = 3.88, TT + TC vs CC genotype), but not with infection nor with the progression from active gastritis to gastric cancer. We also assessed the association of rs2294008 with mRNA expression in the gastric mucosa at various disease stages and found that rs2294008 was associated with expression ( 1.3 × 10). infection ( 5.1 × 10) and eradication therapy ( < 1 × 10) resulted in the reduced and increased expression, respectively, indicating negative regulation of expression by infection. expression was decreased in severe gastritis compared with mild gastritis only among T allele carriers. Our findings revealed the regulation of expression by host genetic variation and bacterial infection might contribute to gastritis progression after infection.