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Spatial multiomic landscape of the human placenta at molecular resolution.
Nat Med
December 2024
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Successful pregnancy relies directly on the placenta's complex, dynamic, gene-regulatory networks. Disruption of this vast collection of intercellular and intracellular programs leads to pregnancy complications and developmental defects. In the present study, we generated a comprehensive, spatially resolved, multimodal cell census elucidating the molecular architecture of the first trimester human placenta.
View Article and Find Full Text PDFAdvancements in skin cancer treatment: focus on photodynamic therapy: a review.
Am J Cancer Res
October 2024
PARC, Arid Zone Research Center Dera Ismail Khan, Pakistan.
Some of these include basal cell carcinoma (BCCs), squamous cell carcinoma (SCCs), and melanoma; skin cancer is a leading global health problem due to its high prevalence and possibly due to its serious health implications. Conventional and known therapies like surgeries, radiation therapies and chemotherapy although helpful are sometime deleterious and do not specifically attack the cancers. New advancement is half-breed technique has recently been recognized that photodynamic therapy (PDT) can be considered as a potentially effective modality by using photosensitizers which work through the generation of localized ROS on exposure to light.
View Article and Find Full Text PDFSlide-tags enables spatial single-nucleus sequencing.
Nat Rev Genet
February 2025
Broad Institute of Harvard and MIT, Cambridge, MA, USA.
root extract exerts anti-TNBC potential by regulating FAK-related signalling pathways.
Am J Cancer Res
September 2024
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University Gwangju 61186, Korea.
Article Synopsis
- LBR, a shrub native to East Asia, has shown promise as an anticancer and antibacterial agent, though its effectiveness against triple-negative breast cancer (TNBC) was previously unclear.
- Research found that LBR’s ethanol extract can cause TNBC cell death by halting cell growth, causing S-phase arrest, and triggering apoptosis.
- RNA sequencing indicated that LBR alters genes related to cell adhesion and inhibits certain cancer-promoting proteins, showing potential as a safe chemotherapeutic option for breast cancer treatment.
Gemcitabine/Cisplatin versus docetaxel, cisplatin and 5-fluorouracil as induction chemotherapy in locally advanced nasopharyngeal carcinoma.
Am J Cancer Res
September 2024
Department of Clinical Oncology, Faculty of Medicine, Tanta University Tanta, Egypt.
Induction chemotherapy followed by concomitant chemoradiation is the standard therapy for patients with locoregionally advanced NPC. There is a limitation of clinical studies that compare different induction regimens. The purpose of this work is to analyze the efficacy of two distinct chemotherapy regimens, docetaxel, cisplatin, and 5-fluorouracil (TPF) and gemcitabine/cisplatin (GP), in treating patients with loco-regionally advanced nasopharyngeal carcinoma (NPC).
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