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| http://dx.doi.org/10.4103/ija.IJA_570_17 | DOI Listing |
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The Human Reference Atlas (HRA) for the healthy, adult body is developed by a team of international, interdisciplinary experts across 20+ consortia. It provides standard terminologies and data structures for describing specimens, biological structures, and spatial positions of experimental datasets and ontology-linked reference anatomical structures (AS), cell types (CT), and biomarkers (B). We introduce the HRA Knowledge Graph (KG) as central data resource for HRA v2.
View Article and Find Full Text PDFUnlabelled: The maturation of RNA is mediated by the coordinated actions of RNA-binding proteins through post-transcriptional pre-mRNA processing. This process is a central regulatory mechanism for gene expression and plays a crucial role in the development of complex biological systems. MYC directly upregulates transcription of genes encoding the core components of pre-mRNA splicing machinery.
View Article and Find Full Text PDFUnlabelled: Bactofilins are a recently discovered class of cytoskeletal protein, widely implicated in subcellular organization and morphogenesis in bacteria and archaea. Several lines of evidence suggest that bactofilins polymerize into filaments using a central β-helical core domain, flanked by variable N- and C-terminal domains that may be important for scaffolding and other functions. However, a systematic exploration of the characteristics of these domains has yet to be performed.
View Article and Find Full Text PDFEffectiveness of interventions to prevent or treat prolonged grief symptoms among families of patients who die in Intensive Care Units: a systematic review protocol.
JBI Evid Synth
January 2025
CINTESIS@RISE, Nursing School of Porto (ESEP), Porto, Portugal.
Objective: The objective of this review is to evaluate the effectiveness of interventions to prevent or treat prolonged grief symptoms among families of patients who die in intensive care units (ICU).
Introduction: Up to 52% of families of patients who die in ICU may be at risk of experiencing prolonged grief symptoms.
Inclusion Criteria: Studies of adult family members (≥18 years) of adult ICU patients (≥18 years) who underwent a treatment withdrawal or withholding decision, and who were exposed to tailored interventions to prevent or treat prolonged grief symptoms before, during, and/or after the patient's death will be considered for inclusion.
We summarise key messages from the World Bank Report . A central lesson of the Report is that in decision-making on the path to Universal Health Coverage (UHC), procedural fairness matters alongside substantive fairness. Decision systems should be assessed using a complete conception of procedural fairness that embodies core commitments to impartial and equal consideration of interests and perspectives.
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