Objective HealthPathways (HPW) is an international web-based information portal that provides health practitioners with guidelines and referral pathways to specialists and services. The present study explored usage of HPW by general practitioners (GPs) in the Barwon region, south-west Victoria, and any benefits and barriers to its use. Methods Approximately 421 GPs provide services in 86 clinics across the Barwon region, south-west Victoria and Barwon Health is the public health service providing acute, subacute, residential aged care and community health services to approximately 350000 people. The present study was a mixed-methods analysis of all GPs in the region, who were invited to complete a survey in two waves (2014 and 2016) and participate in focus groups. Data were survey/questionnaire (fixed response and free text options, analysed with descriptive statistics and content analysis), and focus groups (interview and facilitated group discussion, analysed using the principles of thematic analysis). Results Most GPs surveyed used HPW and usage increased over time from 2014 to 2016 (67% vs 77% respectively). Junior GPs used HPW more often than the more experienced practitioners. GPs reported that HPW was easy to access and navigate, improved their knowledge of local services, improved their confidence, changed their clinical management and saved them time. Main barriers to use of HPW were: GPs did not think to look at HPW, or simply did not know about it. Conclusions HPW has the potential to improve patient management and health outcomes, and use of HPW is increasing over time. What is known about the topic? Initiatives such as HPW are viewed positively by clinicians and have the potential to address challenges at the primary-secondary care interface, specifically, referral to secondary specialists. What does this paper add? Proof of concept that the ongoing availability of localised HPW for common clinical conditions improves GP usage of HPW and has increased access to HPW as the first source of clinical information. Benefits and barriers to use have been identified. What are the implications for practitioners? HPW improves knowledge of local services and provides GPs with easy access to referral pathways.
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http://dx.doi.org/10.1071/AH17090 | DOI Listing |
Inorg Chem
January 2025
Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, P. R. China.
Three cases of aminobenzoic acid hybrid polyoxotungstates, Na(HO)[(HPWO) (OCCHNH)]·7HO (), K(HO)[(AsWO)(OCCHNH)]·4HO (), and [(HN(CH)]Na(HO)[(SbWO) (OCCHNH)]·7HO (), were successfully synthesized. This is the first report of the successful assembly of the hexanuclear {XW} (X = HP, As, or Sb) clusters and organic carboxylic acid (para aminobenzoic acid) ligands. All three hybrids feature a common {XW} unit composed of a six-membered {WO} octahedral ring capped by one {XO} trigonal pyramid.
View Article and Find Full Text PDFComput Biol Med
January 2025
Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Science, 830011, Urumqi, China; University of Chinese Academy of Sciences, 100049, Beijing, China; Xinjiang Laboratory of Minority Speech and Language Information Processing, 830011, Urumqi, China. Electronic address:
N-methyladenosine (mA) plays a crucial role in enriching RNA functional and genetic information, and the identification of mA modification sites is therefore an important task to promote the understanding of RNA epigenetics. In the identification process, current studies are mainly concentrated on capturing the short-range dependencies between adjacent nucleotides in RNA sequences, while ignoring the impact of long-range dependencies between non-adjacent nucleotides for learning high-quality representation of RNA sequences. In this work, we propose an end-to-end prediction model, called mASLD, to improve the identification accuracy of mA modification sites by capturing the short-range and long-range dependencies of nucleotides.
View Article and Find Full Text PDFEnviron Toxicol Pharmacol
December 2024
U S Army Engineer Research and Development Center, Vicksburg, MS, United States.
Neurotoxicity investigations of inhaled organophosphorus pesticide (OP), ethyl-parathion (EP), were conducted in Sprague Dawley rats comparing exposures to EP volatilized at 0, 1, 10, and 20 mg/m versus EP incorporated into soil dust (5 mg/m) at 0, 0.0095, 0.09, and 0.
View Article and Find Full Text PDFBMC Oral Health
December 2024
Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Objective: To assess the color stability and surface roughness of bioactive resin-based composite following exposure to coffee staining and brushing with whitening toothpastes.
Methods: Disk-shaped specimens of Filtek Z250 (FZ), Beautifil Flow Plus (BFP), Activa Presto (AP), and Fuji II LC (FII) were stained with coffee and then brushed with one of three toothpastes, conventional (C-TP), non-peroxide whitening (W-TP) or hydrogen peroxide-containing whitening toothpaste (HPW-TP) for 10 000 cycles. Changes in color (ΔE) and surface roughness were measured.
Nat Commun
December 2024
Laboratory Branch, Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Studies in SIV-infected macaques show that the virus reservoir is particularly refractory to conventional suppressive antiretroviral therapy (ART). We posit that optimized ART regimens designed to have robust penetration in tissue reservoirs and long-lasting antiviral activity may be advantageous for HIV or SIV remission. Here we treat macaques infected with RT-SHIV with oral emtricitabine/tenofovir alafenamide and long-acting cabotegravir/rilpivirine without (n = 4) or with (n = 4) the immune activator vesatolimod after the initial onset of viremia.
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