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Background: Repetitive mild traumatic brain injury (rmTBI) represents a substantial health challenge, urging a more thorough investigation into its early effects and possible interventions. The collective consequences of rmTBI encompass various neurobiological and neuropsychological impairments, increasing susceptibility to diseases like Alzheimer's and related dementias. Employing the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) approach for TBI induction, our prior study revealed connectivity alterations within 53% of regions in young and aged wild-type mice five days post-injury.
View Article and Find Full Text PDFBackground: Traumatic encephalopathy syndrome (TES) is a proposed framework for the clinical syndrome resulting from chronic traumatic encephalopathy and other neurodegenerative effects of repetitive head impacts (RHI). TES symptoms can mirror Alzheimer's disease (AD) despite absence of hallmark AD pathology. We investigated whether GFAP, NfL, and IL-6 correlated with cognition and brain volume changes within TES relative to AD.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
University of Florida, Gainesville, FL, USA.
Background: Repetitive mild traumatic brain injury (rmTBI) represents a substantial health challenge, urging a more thorough investigation into its early effects and possible interventions. The collective consequences of rmTBI encompass various neurobiological and neuropsychological impairments, increasing susceptibility to diseases like Alzheimer's and related dementias. Employing the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) approach for TBI induction, our prior study revealed connectivity alterations within 53% of regions in young and aged wild-type mice five days post-injury.
View Article and Find Full Text PDFThe effects of paced breathing on psychological distress vulnerability and heart rate variability in adults sustaining traumatic injury.
J Affect Disord
January 2025
Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; John Walsh Centre Rehabilitation Research, Northern Sydney Local Health District, St Leonards, Sydney, NSW, Australia.
Background: Traumatic physical injuries can lead to psychological distress and increased risk of psychiatric disorders, often reflected in dysregulated autonomic responses measurable through heart rate variability (HRV). Slow-paced breathing has shown potential in enhancing HRV, but its effectiveness in injured survivors remains unexplored. This study investigates the effect of slow-paced breathing on HRV among injured survivors compared to non-injured individuals and explores the influence of psychological distress and spontaneous respiratory rate on this effect.
View Article and Find Full Text PDFCombining a guided self-help and brief alcohol intervention to improve mental health and reduce substance use among refugee men in Uganda: a cluster-randomized feasibility trial.
Glob Ment Health (Camb)
November 2024
Global Health Section, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Evidence on the effectiveness and implementation of mental health and psychosocial support (MHPSS) interventions for men in humanitarian settings is limited. Moreover, engagement and retention of men in such interventions has been challenging. Adaptations may therefore be required to improve the appropriateness and acceptability of these interventions for men.
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