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Duhuo Jisheng Decoction in reduction of inflammatory response via Transforming growth factor-β/Smad signaling pathway for repairing rabbit articular cartilage Injury: A Randomized Controlled Trial.
Int Immunopharmacol
January 2025
Preventive Treatment of Disease Department, The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, PR China. Electronic address:
Objective: This study aims to investigate the mechanism underlying the effect of Duhuo Jisheng Decoction on the repair of rabbit articular cartilage injury through a reduction in the inflammatory response mediated by the Transforming growth factor (TGF)-β/Smad signaling pathway.
Methods: A rabbit articular cartilage injury model was constructed using a ring bone extraction drill. Twenty-four Japanese white rabbits were randomly divided into six groups, namely Sham operation, model, low-dose Duhuo Jisheng Decoction, medium-dose Duhuo Jisheng Decoction, high-dose Duhuo Jisheng Decoction, and positive control groups.
Low‒Dose Cyclophosphamide Enhances the Tumoricidal Effects of 5-Day Spacing Stereotactic Ablative Radiotherapy by Boosting Antitumor Immunity.
Cancer Res Treat
November 2024
Department of Radiation Oncology, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Purpose: To investigate the potential role of low‒dose cyclophosphamide (Cy) as a radiosensitizer by evaluating its impact on the immune response and the abscopal effect of stereotactic ablative radiotherapy (SABR) through preclinical models.
Materials And Methods: CT26 tumors (immunologically hot) and 4T1 tumors (immunologically cold), grown in immunocompetent BALB/c and immunodeficient BALB/c‒nude mice, were irradiated with 20 Gy in two fractions with 5‒day spacing followed by intraperitoneal injections of 9 mg/kg Cy every 3 days. Immunological changes in CT26 tumors caused by the treatments were assessed using flow cytometry.
Hemostatic bioactivity and mechanism of novel L.-derived carbon dots.
Nanoscale Adv
September 2024
Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine Harbin 150000 China
Article Synopsis
- L. (RCL) Carbonisata, a medicinal plant traditionally used for controlling bleeding, has shown potential for enhancing hemostasis, though its specific active components remain unclear.
- Researchers created novel carbon dots (RCL-CDs) from this plant and characterized their properties using various scientific techniques, finding they had a small average particle size and distinct elemental composition.
- Experimental results in mouse models indicated that RCL-CDs significantly reduced bleeding time and volume, suggesting their efficacy in promoting clotting through changes in fibrinogen levels, platelet counts, and prothrombin time.
Synthetic and natural antibacterial carbon adsorbents for clinical nuclear waste management.
Heliyon
October 2024
Department of Environmental and Public Health, College of Health Sciences, Abu Dhabi University, Abu Dhabi, P.O. Box 59911, United Arab Emirates.
Article Synopsis
- High-dose radioiodine ablation (RAI) therapy requires patients to be isolated due to the large amounts of radioactive waste produced, which must be stored until it is safe to discharge.
- This study explores using graphene oxide silver (GOAg) and bamboo activated carbon (BAC) as alternative materials to effectively extract I-131 from this clinical radioactive wastewater.
- Various scientific analyses (FESEM, XPS, FTIR, XRD) were conducted on the synthesized adsorbents, revealing their structural properties and helping determine their effectiveness in removing radioactive substances.
The dosimetric accuracy of a commercial model-based dose calculation algorithm in modeling a six-groove direction modulated brachytherapy tandem applicator.
Phys Med Biol
October 2024
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, United States of America.
With advancements in high-dose rate brachytherapy, the clinical translation of intensity modulated brachytherapy (IMBT) innovations necessitates utilization of model-based dose calculation algorithms (MBDCA) for accurate and rapid dose calculations. This study uniquely benchmarks a commercial MBDCA, BrachyVision ACUROS(BVA), against Monte Carlo (MC) simulations, evaluating dose distributions for a novel IMBT applicator, termed as theDirection Modulated Brachytherapy (DMBT) tandem, expanding beyond previous focus on partially shielded vaginal cylinder applicators, through a novel methodology.The DMBT tandem applicator, made of a tungsten alloy with six evenly spaced grooves, was simulated using the GEANT4 MC code.
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