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Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree. | LitMetric

Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree.

PLoS One

Department of Immunology, Institute of Immunology and Transfusion Medicine, University Medicine, Greifswald, Germany.

Published: March 2018

AI Article Synopsis

Article Abstract

Sepsis is frequently complicated by a state of profound immunosuppression, in its extreme form known as immunoparalysis. We have studied the role of the adaptive immune system in the murine acute peritonitis model. To read out adaptive immunosuppression, we primed post-septic and control animals by immunization with the model antigen TNP-ovalbumin in alum, and measured the specific antibody-responses via ELISA and ELISpot assay as well as T-cell responses in a proliferation assay after restimulation. Specific antibody titers, antibody affinity and plasma cell counts in the bone marrow were reduced in post-septic animals. The antigen-induced splenic proliferation was also impaired. The adaptive immunosuppression was positively correlated with an overwhelming general antibody response to the septic insult. Remarkably, antigen "overload" by non-specific immunization induced a similar degree of adaptive immunosuppression in the absence of sepsis. In both settings, depletion of regulatory T cells before priming reversed some parameters of the immunosuppression. In conclusion, our data show that adaptive immunosuppression occurs independent of profound systemic inflammation and life-threatening illness.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802895PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192197PLOS

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