The compression physics of powders must be considered when developing a suitable tablet formulation. In the present study, the gravitation-based high-velocity method was utilized to analyze mechanical properties of eight common pharmaceutical excipients: two grades of lactose, anhydrous glucose, anhydrous calcium hydrogen phosphate, three grades of microcrystalline cellulose and starch. Samples were compressed five times consecutively with varying pressure and speed so that Setup A produced higher pressure and longer contact time than Setup B. The important parameters obtained from samples were porosity profiles, compaction pressure, contact time, internal energy change and the amount of elastic recovery. All acquired data was only based on distance-time profile of the compression event. Lactose and glucose fragmented effectively while calcium hydrogen phosphate remained in rearrangement phase, due to its hardness and insufficient pressure applied. Microcrystalline cellulose samples showed plastic behaviour and starch was most elastic of all the samples. By utilizing the method, examined excipients could be categorized according to their compression behaviour in an accurate and cost-efficient manner.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2018.01.048 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dentin remineralization induced by experimental composites containing calcium orthophosphate particles.
Dent Mater
December 2024
University of São Paulo School of Dentistry, Department of Biomaterials and Oral Biology, Av. Prof. Lineu Prestes, 2227, São Paulo, SP 05508-000, Brazil. Electronic address:
Objectives: This study aimed to verify if composites containing dicalcium phosphate dihydrate particles (DCPD) are able to induce dentin remineralization in vitro. Additionally, the mechanical properties of the materials were tested.
Methods: Four composites with 50 vol% inorganic content and 1 BisGMA: 1 TEGDMA (mols) were prepared, with different DCPD:glass ratios (50:0, 40:10, 30:20 and 0:50).
High-performance supercapacitors based on coarse nanofiber bundle and ordered network hydrogels.
Int J Biol Macromol
December 2024
Jiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China; Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture and Rural Affairs, Sericultural Scientific Research Center, Chinese Academy of Agricultural Sciences, Zhenjiang 212100, China.
Most of the developed flexible hydrogel supercapacitors struggle to maintain their electrochemical stability and structural integrity under tensile strain. Therefore, developing a flexible supercapacitor with excellent mechanical properties and stable electrochemical performance under different strains remains a challenge. Based on the previous cartilage-like structure, we designed a new coarse nanofiber bundle and ordered network.
View Article and Find Full Text PDFEco-friendly cellulose paper composites: A sustainable solution for EMI shielding and green engineering applications.
Int J Biol Macromol
December 2024
International and Inter-University Centre for Nanoscience and Nanotechnology (IIUCNN), Mahatma Gandhi University, Kottayam, Kerala 686 560, India; School of Energy Materials, Mahatma Gandhi University, Kottayam, Kerala 686560, India; School of Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala 686560, India; Department of Chemical Sciences, University of Johannesburg, P.O.Box 17011, Doornfontein, 2028 Johannesburg, South Africa; Trivandrum Engineering, Science and Technology (TrEST) Research Park, Trivandrum 695016, India. Electronic address:
Cellulose paper-based composites represent a promising and sustainable alternative for electromagnetic interference (EMI) shielding applications. Derived from renewable and biodegradable cellulose fibers, these composites are enhanced with conductive fillers namely carbon nanotubes, graphene, or metallic nanoparticles, achieving efficient EMI shielding while maintaining environmental friendliness. Their lightweight, flexible nature, and mechanical robustness make them ideal for diverse applications, including wearable electronics, flexible circuits, and green electronics.
View Article and Find Full Text PDFAcrylamide/Alyssum campestre seed gum hydrogels enhanced with titanium carbide: Rheological insights for cardiac tissue engineering.
Int J Biol Macromol
December 2024
Department of Petroleum Engineering, Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran; Polymer Synthesis Technology, School of Chemical Engineering, Aalto University, Espoo, Finland.
This study investigates the use of acrylamide and Alyssum campestre seed gum (ACSG) to create hydrogel composites with enhanced electrical and mechanical properties by incorporating titanium carbide (TiC). The composites were analyzed through techniques such as FTIR, SEM, TEM, TGA, swelling, rheology, tensile, electrical conductivity, antibacterial, and MTT assays. XRD analysis showed that 0.
View Article and Find Full Text PDFConductive polyacrylamide/pullulan/ammonium sulfate hydrogels with high toughness, low-hysteresis and tissue-like modulus as flexible strain sensors.
Int J Biol Macromol
December 2024
College of Materials Science and Engineering, Nanjing Tech University, Nanjing 210009, China.
Conductive hydrogels have great potential for applications in flexible wearable sensors due to the combination of biocompatibility, mechanical flexibility and electrical conductivity. However, constructing conductive hydrogels with high toughness, low hysteresis and skin-like modulus simultaneously remains challenging. In the present study, we prepared a tough and conductive polyacrylamide/pullulan/ammonium sulfate hydrogel with a semi-interpenetrating network.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!