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A comprehensive review on the development of sporadic cerebral arteriovenous malformations: from Padget to next-generation sequencing.
J Neurosurg
August 2024
1Department of Neurological Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina; and.
Cerebral arteriovenous malformations (AVMs) are a leading cause of intracerebral hemorrhage in both children and young adults. With the continued advancement of science and technology, the understanding of the pathophysiology behind the development of these lesions has evolved. From early theory published by Harvey Cushing and Percival Bailey in 1928, Tumors Arising from the Blood-vessels of the Brain: Angiomatous Malformations and Hemangioblastoma, which regarded AVMs as tumors arising from blood vessels, to the meticulous artistry of Dorcas Padget's embryological cataloguing of the cerebral vasculature in 1948, to the proliferative capillaropathy theory of Yaşargil in 1987, to Ramey's 2014 hierarchical model of vascular development, there have been multiple hypotheses of congenital, developmental, and genetic two-hit theories in the pathogenesis of AVMs.
View Article and Find Full Text PDFVascular Surgery Role in Vascular Trauma: 11-Year Analysis of Peripheral Vascular Trauma Management at a Level-1 Trauma Center.
Ann Vasc Surg
July 2023
Division of Acute Care Surgery, University of New Mexico School of Medicine, Albuquerque, NM; Division of Vascular Surgery, University of New Mexico School of Medicine, Albuquerque, NM.
Background: Vascular surgeons are increasingly relied upon in the management of complex peripheral vascular trauma. The degree however that vascular surgery (VS) is involved in vascular trauma care is not well established. We hypothesize that VS consultation is required in a high portion of complex lower extremity vascular trauma.
View Article and Find Full Text PDF"Did I just do that?"-Six-month-olds learn the contingency between their vocalizations and a visual reward in 5 minutes.
Infancy
November 2021
Department of Health Sciences, University of York, York, UK.
It has been shown that infants can increase or modify a motorically available behavior such as sucking, kicking, arm waving, etc., in response to a positive visual reinforcement (e.g.
View Article and Find Full Text PDFDevelopment and Feasibility Study of an Addiction-Focused Phenotyping Assessment Battery.
Am J Addict
July 2021
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia.
Background And Objectives: Current methods of classifying individuals with substance use disorder (SUD) result in vast heterogeneity among persons within a given diagnosis. These approaches, while clinically allowing for distinctions between patient groups, are less than ideal when attempting to recruit a neurobehaviorally defined subset of subjects into clinical trials. To address this gap, alternative strategies have been proposed, including behavioral phenotyping.
View Article and Find Full Text PDFNeurovascular Relations in Modified Iliac Screws and Traditional Iliac Screw: Anatomic Study.
World Neurosurg
February 2020
Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington, USA; Seattle Science Foundation, Seattle, Washington, USA.
Background: This study describes a modified iliac screw technique and compares it with the traditional iliac screw in regard to neurovascular structures at risk. Few studies have detailed the insertion point's surrounding anatomy and its relationship to vulnerable neurovascular structures when this modified technique is used. Therefore we describe our modified iliac screw entry and trajectory and detail the surrounding anatomy and neurovascular structures at risk with this technique in comparison with the "gold standard" trajectory.
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