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| http://dx.doi.org/10.1016/j.jaac.2017.11.018 | DOI Listing |
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Funmap: integrating high-dimensional functional annotations to improve fine-mapping.
Bioinformatics
January 2025
Department of Biostatistics, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong, China.
Motivation: Fine-mapping aims to prioritize causal variants underlying complex traits by accounting for the linkage disequilibrium of GWAS risk locus. The expanding resources of functional annotations serve as auxiliary evidence to improve the power of fine-mapping. However, existing fine-mapping methods tend to generate many false positive results when integrating a large number of annotations.
View Article and Find Full Text PDFNovel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study.
Sci Rep
December 2024
Department of Anesthesiology, Shanxi Hospital Affiliated to Cancer Hospital, Shanxi Province Cancer Hospital, Chinese Academy of Medical Sciences, Taiyuan, China.
Atopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current studies reveal the underlying mechanisms of these loci in the pathogenesis of AD inadequately.
View Article and Find Full Text PDFThe shared genetic landscape of polycystic ovary syndrome and breast cancer: convergence on ER + breast cancer but not ER- breast cancer.
Breast Cancer Res
November 2024
Department of Breast Surgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Background: The clinically high comorbidity between polycystic ovary syndrome (PCOS) and breast cancer (BC) has been extensively reported. However, limited knowledge exists regarding their shared genetic basis and underlying mechanisms.
Method: Leveraging summary statistics from the largest genome-wide association studies (GWASs) to date, we conducted a comprehensive genome-wide cross-trait analysis of PCOS and BC.
Causality between autoimmune diseases and schizophrenia: a bidirectional Mendelian randomization study.
BMC Psychiatry
November 2024
Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Article Synopsis
- This study investigates the relationship between autoimmune diseases and schizophrenia through a Mendelian randomization analysis in individuals of European descent, addressing previous conflicting findings.
- Results suggest that ankylosing spondylitis increases the risk of schizophrenia, while celiac disease, type 1 diabetes, and systemic lupus erythematosus may decrease it; conversely, schizophrenia is related to higher risks of some autoimmune conditions.
- The research highlights a potential causal connection between autoimmune diseases and schizophrenia, emphasizing the need for further studies to explore the underlying mechanisms.
Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies.
HGG Adv
January 2025
Graduate School of Data Science, Seoul National University, Seoul, Republic of Korea; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most of the causal mechanisms of lipids remain unknown. To better understand the biological processes underlying lipid metabolism, we investigated the associations of plasma protein levels with total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol in blood.
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