AI Article Synopsis
- - The study investigates how carotid intima media thickness (cIMT) relates to body mass index (BMI) and cardiovascular (CV) risk in children aged 6-18, revealing both BMI and CV risk score are significantly correlated with cIMT.
- - Analyzing data from 291 children, researchers found cIMT remains stable from childhood through adolescence, but it shows small positive correlations with both BMI (r = 0.14) and CV risk score (r = 0.16).
- - The findings suggest that keeping BMI and CV risk factors in check could help prevent early signs of preclinical atherosclerosis in children.
Article Abstract
Background: Measures of carotid intima media thickness (cIMT) in adults are correlated with adiposity and the metabolic syndrome (MetS) and predict cardiovascular (CV) events. Relations in children are not as well studied. Our objective was to determine the relations of cIMT with body mass index (BMI) and CV risk score in children.
Methods: The study included 291 children (158 M/133 F) 6-18 years of age (140 aged 6-11/151 aged 12-18) with measurements of height, weight, waist circumference; fasting lipids, glucose, insulin, and cIMT. A CV risk cluster score was developed from sum of the z-scores of the five MetS components (waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, and insulin). Partial Pearson correlation coefficients were adjusted for age, sex, and race.
Results: There was no significant age difference in cIMT from 6 to 18 years of age. BMI and CV risk score were significantly correlated (P < 0.0001), and both were correlated with cIMT (r = 0.14, P = 0.02 and r = 0.16, P = 0.006, respectively). Slight age-related differences in associations of cIMT with CV risk score and BMI were explained by unusual values in a few children.
Conclusions: These cross-sectional data in normal children show that cIMT was stable from childhood into adolescence. However, both BMI and CV risk score had small, but significant positive correlations with cIMT. Therefore, maintaining normal levels of adiposity and other risk variables may be useful in preventing early changes associated with preclinical atherosclerosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878544 | PMC |
| http://dx.doi.org/10.1089/met.2017.0149 | DOI Listing |
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Article Synopsis
- This systematic review investigates how body composition, particularly skeletal muscle mass, impacts vascular health measures like arterial stiffness and structure.
- Researchers conducted a thorough literature search and included 15 observational studies with over 21,000 participants, assessing various vascular health indices.
- The findings show that higher fat-free mass correlates positively with carotid artery thickness, while body fat percentage is linked to arterial stiffness, indicating a need for further research on specific body composition factors and their health implications.
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