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Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner. | LitMetric

Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner.

Org Biomol Chem

Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, USA.

Published: February 2018

AI Article Synopsis

Article Abstract

In the course of generating a library of open-chain epothilones, we discovered a new class of small molecule anticancer agents that has no effect on tubulin but instead kills selected cancer cell lines by harnessing reactive oxygen species in an iron-dependent manner. Results of the preliminary studies are consistent with the recently described cell death mechanism ferroptosis. Studies are in progress to confirm ferroptosis as the cell death mechanism and to identify the specific molecular targets of these small molecule anticancer agents.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337851PMC
http://dx.doi.org/10.1039/c7ob03086jDOI Listing

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