AI Article Synopsis
- The study explores using mitochondria, which originate from bacteria, as a new method for delivering carbon quantum dots (CQDs) and the chemotherapy drug doxorubicin (DOX) to treat cancer.
- Results indicate that mitochondria effectively carry CQDs while maintaining their optical properties and improve the distribution and retention of these particles in organs after being injected.
- The mitochondria-based delivery system, named Mito-DOX, demonstrates enhanced cancer treatment effects compared to traditional free DOX, highlighting its potential as a novel approach in cancer therapy and biological imaging.
Article Abstract
The application of engineered bacteria-based drug delivery vehicles to treat cancer has been practiced for more than a century. Mitochondria, evolutionarily originated from bacteria, are ubiquitous, semi-autonomous cellular organelles. In this study, we present the first exploration of using mitochondria as a delivery system of carbon quantum dots (CQDs) for in vivo imaging and administration of the anticancer drug doxorubicin (DOX). The results show that mitochondria as carriers are compatible with CQD loading and preserve the optical properties of CQDs. Moreover, the mitochondria delivery system can improve the CQD bio-distribution in organs and prolong the retention time of CQDs after intravenous injection. Furthermore, mitochondria loaded with doxorubicin hydrochloride (Mito-DOX) show an enhanced therapeutic effect compared to free DOX. The mitochondria-based "aircraft" system may be a promising novel therapeutic platform with high potential for biological imaging and drug delivery to fight cancer and other diseases.
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| http://dx.doi.org/10.1039/c7nr08816g | DOI Listing |
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