Evidence of ferroelasticity in a non-planar organic molecular crystal is presented for 4,4'-dicarboxydiphenyl ether. Ferroelasticity has been demonstrated by the micro- and macroscopic mechanical characterization of single crystals, including recording of a full hysteretic stress-strain cycle. The underlying mechanism involves the partial flipping of phenyl rings.
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http://dx.doi.org/10.1098/rsos.171146 | DOI Listing |
Brain Behav Immun
February 2025
Department of Anatomy, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, 510006, China. Electronic address:
Prenatal virus infection-induced maternal immune activation (MIA) is linked to a greater risk of neurodevelopmental disorders in offspring. Prenatal exposure to poly(I:C) in pregnant mice is a well-established approach to mimic virus infection-induced MIA, leading to neuropsychiatric disorders and aberrant brain development, especially in the medial prefrontal cortex (mPFC). ATPase phospholipid flippase 8A2 (ATP8A2) is the main phospholipid lipase, expressed in the mPFC and is crucial for maintaining cell membrane stability by flipping phosphatidylserine from the outer leaflet to the inner leaflet of the cell membrane.
View Article and Find Full Text PDFNat Commun
October 2024
State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin, 300071, China.
Base excision repair (BER) is initialized by DNA glycosylases, which recognize and flip damaged bases out of the DNA duplex into the enzymes active site, followed by cleavage of the glycosidic bond. Recent studies have revealed that all types of DNA glycosylases repair base lesions less efficiently within nucleosomes, and their repair activity is highly depended on the lesion's location within the nucleosome. To reveal the underlying molecular mechanism of this phenomenon, we determine the 3.
View Article and Find Full Text PDFJ Craniofac Surg
September 2024
Suez Canal University Hospitals, Ismailia, Egypt.
Background: Traumatic ear amputation is a rare injury. Ear replantation is the gold standard in dealing with amputated ears. However, this is not always feasible.
View Article and Find Full Text PDFRNA
June 2024
Department of Microbiology and Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, USA
30S subunits become inactive upon exposure to low Mg concentration, because of a reversible conformational change that entails nucleotides (nt) in the neck helix (h28) and 3' tail of 16S rRNA. This active-to-inactive transition involves partial unwinding of h28 and repairing of nt 921-923 with nt 1532-1534, which requires flipping of the 3' tail by ∼180°. Growing evidence suggests that immature 30S particles adopt the inactive conformation in the cell, and transition to the active state occurs at a late stage of maturation.
View Article and Find Full Text PDFMicrosurgery
May 2024
Department of Ear, Nose and Throat, Ege University Faculty of Medicine, Izmir, Turkey.
Introduction: The pectoral myocutaneous flap (PMF) is a workhorse regional reconstructive option for head and neck defects. It is commonly used for primary reconstructions due to its advantages or as a life-boat flap in the salvage of failed reconstructions of free flaps. However, it also has intrinsic drawbacks, such as perfusion problems and partial or complete flap loss.
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