In 1976, the toll of cancer in Denmark (5 million inhabitants) was 12,481 deaths, or 23% of deaths from all causes. Seven manifestations accounted for more than half of the cancer deaths, namely lung (19%), breast (9%), stomach (7%), colon (9%), rectum (5%), pancreas (6%) and prostate (5%). The median age of the cancer patients was 70 years, ranging from 65 years for breast cancer patients to 75 years for those with prostate cancer. Cancer caused a reduction in the patients' normal life-span; it totalled 182,486 years for all the dead patients, 37% of which were in productive age. The future caseload was projected from the time trend for the years 1968-76. During the following five years an annual increase by 200 deaths is expected. The trend differs between the seven major manifestations, since some will increase and others will stabilize or decrease. When case reports are combined with mortality data, survival tables can be produced. Follow-up surveys of the patient's health, combined with modern data processing, can produce a detailed description of the impact of cancer on the patient's life. These health tables, which illustrate the natural history of the disease, can also be used to assess new therapeutic regimens.
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J Exp Clin Cancer Res
January 2025
Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a second-line treatment with curative potential for leukemia patients. However, the prognosis of allo-HSCT patients with disease relapse or graft-versus-host disease (GvHD) is poor. CD4 or CD8 conventional T (Tconv) cells are critically involved in mediating anti-leukemic immune responses to prevent relapse and detrimental GvHD.
View Article and Find Full Text PDFJ Transl Med
January 2025
Department of Gynecology, The Fourth Hospital of Hebei Medical University, No.12 Jiankang Road, Shijiazhuang, 050000, Hebei, China.
Background: Immune cells within tumor tissues play important roles in remodeling the tumor microenvironment, thus affecting tumor progression and the therapeutic response. The current study was designed to identify key markers of plasma cells and explore their role in high-grade serous ovarian cancer (HGSOC).
Methods: We utilized single-cell sequencing data from the Gene Expression Omnibus (GEO) database to identify key immune cell types within HGSOC tissues and to extract related markers via the Seurat package.
J Ovarian Res
January 2025
Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.
Infect Agent Cancer
January 2025
Shahid Beheshti University of Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.
Both women and men are now confronted with the grave threat of cancers caused by the human papillomavirus (HPV). It is estimated that 80% of women may encounter HPV over their lives. In the preponderance of cases involving anal, head and neck, oral, oropharyngeal, penile, vaginal, vulvar, and cervical malignancies, high-risk HPV (HR-HPV) is the causative agent.
View Article and Find Full Text PDFMol Cancer
January 2025
Department of Radiation Oncology, Peking University Third Hospital, Beijing, 100191, China.
Background: Sorafenib, an FDA-approved drug for advanced hepatocellular carcinoma (HCC), faces resistance issues, partly due to myeloid-derived suppressor cells (MDSCs) that enhance immunosuppression in the tumor microenvironment (TME).
Methods: Various murine HCC cell lines and MDSCs were used in a series of in vitro and in vivo experiments. These included subcutaneous tumor models, cell viability assays, flow cytometry, immunohistochemistry, and RNA sequencing.
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