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Through the analysis of data from children aged 6 months to 8 years enrolled in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), significant simultaneous associations were identified between variants in the fragile histidine triad () gene, children's body mass index, microbiome features related to obesity, and key lipids and amino acids. These patterns represent evidence of the genotype influence in shaping the host microbiome in developing stages and new potential biomarkers for childhood obesity, insulin resistance, and type 2 diabetes.
View Article and Find Full Text PDFSerum miR-365b-5p/miR-222-5p as a potential diagnostic biomarker for long-term weight loss in patients with morbid obesity after bariatric surgery.
Metabolism
December 2024
Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga, Spain; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Malaga, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Madrid, Spain.
Background: The successful weight loss following bariatric surgery is not achieved in all patients with morbid obesity (MO). This study aims to determine whether a serum miRNA profile can predict this outcome.
Design: Thirty-three patients with MO were classified in "Good Responders" (GR, percentage of excess weight loss (%EWL) ≥ 50 %) or "Non-Responders" (NR, %EWL < 50 %) according to the %EWL 5-8 year following bariatric surgery.
Concordance Between Hemoglobin and Hematocrit Among Children and Pregnant Persons in National Health and Nutrition Examination Survey Data, 1999-2020.
J Nutr
December 2024
International Micronutrient Malnutrition Prevention and Control (IMMPaCt) Program, Nutrition Branch, Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address:
Article Synopsis
- Hemoglobin and hematocrit are common tests to identify anemia, but their results can differ significantly, particularly in children and pregnant individuals.
- The study analyzed data from 7,052 children and 1,437 pregnant persons, revealing that anemia estimates based on hemoglobin and hematocrit varied, with a notable percentage detected by only one test.
- The findings suggest that using these biomarkers interchangeably could lead to underdiagnosis and lack of treatment for anemia, emphasizing the need for accurate assessments in clinical practice.
Obesity and insulinopenic type 2 diabetes differentially impact, bone phenotype, bone marrow adipose tissue, and serum levels of the cathelicidin-related antimicrobial peptide in mice.
Bone
December 2024
Marrow Adiposity and Bone Lab, MABLab-ULR4490, Univ. Littoral Côte d'Opale F-62200 Boulogne-sur-Mer, Univ. Lille F-59000 Lille, CHU Lille, F-59000 Lille, France. Electronic address:
Obesity is a risk factor of developing type 2 diabetes (T2D) and metabolic complications, through systemic inflammation and insulin resistance. It has also been associated with increased bone marrow adipocytes along with increased bone fragility and fracture risk. However, the differential effects of obesity and T2D on bone fragility remain unclear.
View Article and Find Full Text PDFAge-Specific Effect and Pathways of Risk Factors on the Risk of Incident Type 2 Diabetes: A 13-Year Prospective Cohort Study.
Diabetes Metab Res Rev
January 2025
Department of Epidemiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Aim: To assess risk profiles and pathways for incident type 2 diabetes by age at onset.
Materials And Methods: Based on the Kailaun study, 92,020 participants without type 2 diabetes were enrolled and classified into four age-onset groups as < 55, 55 to < 65, 65 to < 75, and ≥ 75 years. Clinical risk factors and serum biomarkers were examined.
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