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Recovery from antibody-mediated biliary ductopenia and multiorgan inflammation after COVID-19 vaccination.
NPJ Vaccines
April 2024
Department of Surgery, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan South Road, Taipei, 100, Taiwan.
The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality. Spike messenger RNA (mRNA)-based vaccines against severe acute respiratory syndrome coronavirus 2 may contribute to immune-mediated injuries. Here we present a case of a previously healthy 47-year-old man, who developed progressive jaundice 2 weeks after receiving his 3 COVID-19 vaccination (1 mRNA-based vaccine).
View Article and Find Full Text PDFLoss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.
Mol Metab
May 2024
Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludgwig-Maximilians-University Munich, Germany. Electronic address:
Objective: The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether GIP regulates body weight and glucose control via GIPR signaling in cells that express the leptin receptor (Lepr).
Methods: Hypothalamic, hindbrain, and pancreatic co-expression of Gipr and Lepr was assessed using single cell RNAseq analysis.
Immunological and virological triggers of type 1 diabetes: insights and implications.
Front Immunol
January 2024
Diabetes Research Institute (DRI), University of Miami Miller School of Medicine, Miami, FL, United States.
Type 1 diabetes (T1D) is caused by an autoimmune process which culminates in the destruction of insulin-producing beta cells in the pancreas. It is widely believed that a complex and multifactorial interplay between genetic and environmental factors, such as viruses, play a crucial role in the development of the disease. Research over the past few decades has shown that there is not one single viral culprit, nor one single genetic pathway, causing the disease.
View Article and Find Full Text PDFVanishing contrast material from presumed biliary system secondary to portal venous injection in the setting of ampullary tumor (with video).
Gastrointest Endosc
October 2023
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Spectral Computed Tomography-Derived Iodine Content and Tumor Response in the Follow-Up of Neuroendocrine Tumors-A Single-Center Experience.
Curr Oncol
January 2023
Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353 Berlin, Germany.
Article Synopsis
- Spectral computed tomography (SCT) enables the calculation of iodine content (IC) to help characterize hypervascularized neuroendocrine tumors (NETs) for better staging.
- A study involving 26 patients with metastasized NETs assessed the relationship between SCT-derived IC values and tumor response over a median follow-up of 64 weeks.
- Results showed that higher IC in lymphonodular metastases correlated with reduced disease progression, while patterns in liver and pancreatic metastases were less clear after accounting for other factors like treatment and tumor grade.
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