Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4CD25CD127FOXP3) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924714 | PMC |
| http://dx.doi.org/10.1016/j.humimm.2018.01.010 | DOI Listing |
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