AI Article Synopsis
- Two studies were performed to evaluate the mutagenic and genotoxic effects of aspartame.
- In a bacterial reverse mutation test, various strains of bacteria exposed to high concentrations of aspartame showed no signs of mutation.
- Similarly, a study in mice showed that administering aspartame did not lead to an increase in cells with genetic damage in their bone marrow.
- Overall, the findings indicate that aspartame has no mutagenic or genotoxic potential.
Article Abstract
Two studies were conducted to further assess its mutagenic and genotoxic potential. In a bacterial reverse mutation pre-incubation study, Salmonella typhimurium strains TA100, TA1535, TA98, and TA1537 and Escherichia coli WP2 uvrA were treated with aspartame at concentrations of up to 5000 μg/plate with or without metabolic activation and showed no mutagenic potential. Similarly, in vivo micronucleus testing of aspartame following gavage administration (500-2000 mg/kg body weight) to Crlj:CD1(ICR) strain SPF male mice showed no increase in the proportion of micronucleated polychromatic erythrocytes in bone marrow cells collected and evaluated 24 or 48 h post administration. Overall, aspartame had no potential for mutagenic or genotoxic activity.
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| http://dx.doi.org/10.1016/j.yrtph.2018.01.023 | DOI Listing |
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