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Alpha 1 adrenergic receptor-mediated inflammatory responses in human testicular peritubular cells. | LitMetric

AI Article Synopsis

  • Stress impacts male fertility by activating the sympathetic nervous system and affecting testicular cells.
  • Human testicular peritubular cells (HTPCs) respond to catecholamines, increasing certain inflammatory markers when stimulated by α1-adrenergic receptors.
  • Blocking these α1-adrenergic receptors could potentially mitigate stress-related fertility issues in men by reducing inflammation in the testes.

Article Abstract

Stress activates the sympathetic nervous system and is linked to impaired fertility in man. We hypothesized that catecholamines by acting on testicular cells have a role in these events, possibly by fostering an inflammatory environment. The cells of the wall of seminiferous tubules, human testicular peritubular cells (HTPCs), express adrenergic receptors (ADRs) α1B, α1D, β1 and β2. A selective α1-ADR agonist, phenylephrine, increased intracellular Ca-levels in cultured HTPCs and induced COX-2, IL-6 and MCP-1 mRNA expression without affecting IL-1β mRNA. These changes were paralleled by a significant increase in the secretion of IL-6 and MCP-1. Epinephrine was also effective, but salbutamol, a selective β2-ADR agonist was not. Our results suggest that stress-associated elevation of catecholamines may be able to promote inflammatory events by targeting peritubular cells in the human testis. Blockage of α1-ADRs may therefore be a novel way to interfere with stress-related impairment of male reproductive functions.

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Source
http://dx.doi.org/10.1016/j.mce.2018.01.027DOI Listing

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