Introduction: Tremor dominant (TD), postural instability/gait difficulty (PIGD), and akinetic-rigid (AR) subtypes are widely used in classifying patients with Parkinson's disease (PD).
Methods: We compared clinical characteristics between PD subtypes in a large retrospective cohort. Between 1998 and 2016, we included a total of 1003 patients with PD in this retrospective study. Six hundred ninety-four patients had more than one visit. Data were collected regarding motor/non-motor symptoms at the initial/final visits. Based on the prominent symptom at the initial visit, we classified patients into one of the four subtypes: TD, AR, gait difficulty, and mixed. Rapid progression was defined by emergence of falls, dementia, or dependency within 5years after onset.
Results: TD was the most prevalent subtype (44%), followed by AR (29%), mixed (18%), and gait difficulty (9%). Rapid progression was observed more frequently in gait difficulty compared to AR (OR: 3.59 P<0.001). Hallucinations at the final visit were more likely to occur in AR (OR: 2.36, P=0.005) and mixed (OR: 3.28, P<0.001) compared to TD.
Conclusions: Our findings provide support for a distinction of four different PD subtypes: TD, AR, gait difficulty, and mixed. The gait difficulty subtype was distinguishable from the AR subtype.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jns.2018.01.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Soleo Health, Frisco, TX, USA.
Background: The approval of anti-amyloid monoclonal antibodies (mAbs) provides a novel approach to the treatment of Alzheimer's disease. Infusions in alternative sites of care can benefit the patient financially and logistically, but coverage is largely payor dependent. The purpose of this study is to describe observations from this national complex specialty pharmacy around the safety of anti-amyloid mAb infusions in alternative sites of care, including the home.
View Article and Find Full Text PDFResearch on Controllable Synthesis and Growth Mechanism of Sodium Vanadium Fluorophosphate Nanosheets.
Recent Pat Nanotechnol
January 2025
Ansteel Beijing Research Institute Co., Ltd., Beijing 102211, China.
Background: Sodium vanadium fluorophosphate is a sodium ion superconductor material with high sodium ion mobility and excellent cyclic stability, making it a promising cathode material for sodium-ion batteries. However, most of the literature and patents report preparation through traditional methods, which involve complex processes, large particle sizes, and low electronic conductivity, thereby limiting development progress.
Objective: Aiming at the limitation of high cost and poor performance of vanadium sodium fluorophosphate cathode material, the low temperature and high-efficiency nano preparation technology was developed.
A park-based group mobility program for older adults with difficulty walking outdoors: a qualitative process evaluation of the Getting Older Adults Outdoors (GO-OUT) randomized controlled trial.
BMC Geriatr
January 2025
Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada.
Background: The Getting Older Adults Outdoors (GO-OUT) randomized controlled trial showed that a workshop and 10-week park-based outdoor walk group (OWG) was superior to the workshop and 10 weekly reminders (WR) with increasing walking capacity, but not outdoor walking activity, health-promoting behavior, or successful aging, among older adults with difficulty walking outdoors. The objective of this planned process evaluation was to explore participants' perceptions of mechanisms of impact of and contextual factors influencing experiences with the interventions to help explain the observed intervention effects on study outcomes.
Methods: A qualitative descriptive study involving semi-structured interviews conducted at 6-months post-baseline was conducted.
Clinical Reasoning: A 62-Year-Old Woman With Progressive Spasticity, Weakness, and Gait Instability.
Neurology
February 2025
From the Department of Neurosciences, University of California, San Diego School of Medicine.
Evaluating patients with adult-onset gait instability can pose diagnostic challenges. In this case, a 62-year-old Ashkenazi Jewish woman with a history of surgically corrected hammer toes presented with chronic progressive lower extremity weakness, sensory impairment, and gait instability. Subsequently, the patient developed urinary urgency and mild cognitive difficulties.
View Article and Find Full Text PDFThe role of river connectivity in the distribution of fish in an anthropized watershed.
Sci Total Environ
January 2025
University of Paris-Saclay, INRAE, HYCAR, Antony, France.
The ongoing biodiversity crisis is especially severe in freshwater habitats. Anthropized watersheds, such as the Seine-Normandie basin in France, are particularly affected by human interference. The study of fish species distribution in watersheds often relies on environmental drivers such as land use or climate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!