Background: The Bernese periacetabular osteotomy (PAO) is an alternative to arthroplasty for treating symptomatic acetabular dysplasia, but there have been few studies on the intermediate-term outcomes of this procedure. In the present study, we assessed intermediate-term hip survival and patient-reported outcomes of PAO used to treat symptomatic acetabular dysplasia.
Methods: From July 1994 to August 2008, 238 hips (206 patients) were treated with PAO. Sixty-two had a diagnosis other than classic acetabular dysplasia, and 22 were lost to follow-up. The remaining 154 hips (129 patients) were evaluated at an average of 10.3 years postoperatively. Kaplan-Meier analysis was used to assess survivorship with an end point of total hip arthroplasty (THA). Hips were evaluated using the University of California at Los Angeles (UCLA) Activity Score, modified Harris hip score (mHHS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score. A WOMAC pain subscale score of ≥10 and/or an mHHS of ≤70 were considered to indicate a clinically symptomatic hip.
Results: Kaplan-Meier analysis revealed a hip survival rate of 92% (95% confidence interval [CI]: 82% to 97%) at 15 years postoperatively. Eight hips (5%) underwent THA at a mean (and standard deviation) of 6.8 ± 5.2 years. Twenty-four additional hips (16%) were considered symptomatic based on a WOMAC pain score of ≥10 and/or an mHHS of ≤70. One hundred and twenty-two hips (79%) did not undergo THA and did not meet the criteria for symptoms, and these hips had a mean mHHS of 92.4 ± 8.4, WOMAC pain subscale score of 1.2 ± 1.9, and UCLA Activity Score of 7.7 ± 2.0 at a mean of 10.1 years. A higher risk of failure was associated with fair or poor preoperative joint congruency (odds ratio [OR]: 8.65; 95% CI: 1.18 to 63.55; p = 0.034) and with a postoperative lateral center-edge angle of >38° (OR: 8.04; 95% CI: 2.01 to 32.22). A concurrent head-neck osteochondroplasty was associated with a decreased risk of failure (OR: 0.27; 95% CI: 0.09 to 0.78; p = 0.016).
Conclusions: This study demonstrates the durability of the Bernese PAO. Fair or poor preoperative joint congruency and excessive postoperative femoral head coverage were found to be predictors of failure, while concurrent head-neck osteochondroplasty in patients with an inadequate range of motion after PAO was associated with a decreased risk of failure.
Level Of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
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http://dx.doi.org/10.2106/JBJS.17.00337 | DOI Listing |
Cureus
December 2024
Clinical Research and Medical Writing, Meril Life Sciences Private Limited, Vapi, IND.
Aim The primary objective of the study was to evaluate the mid-term implant survivability, rate of revisions, and clinical and functional outcomes following patella resurfacing during total knee arthroplasty (TKA) utilizing posterior stabilized (PS) total knee system (TKS). Methods A prospective, single-arm, multi-center, post-marketing surveillance encompassed patients with end-stage primary knee osteoarthritis (OA) or inflammatory arthritis. The time points of the study included baseline, six weeks, six months, one year, and three years post-operatively.
View Article and Find Full Text PDFClin Exp Rheumatol
January 2025
UMass Chan Medical School and UMass Memorial Medical Center, Boston, MA, USA.
Objectives: To assess the efficacy and safety of an intra-articular (IA) CLK/DYRK inhibitor, lorecivivint (LOR), for the treatment of moderate to severe symptomatic knee osteoarthritis (OA).
Methods: This was a Phase 3, 28-week, multicentre, double-blind, placebo-controlled study evaluating the efficacy and safety of a single IA injection of LOR. Patients with ACR-defined knee OA, Kellgren-Lawrence (KL) grades 2-3, and pain Numeric Rating Scale (NRS) ≥4 and ≤8 in the target knee were randomised (1:1) to receive LOR 0.
Clin Exp Rheumatol
January 2025
UMass Chan Medical School and UMass Memorial Medical Center, Boston, MA, USA.
Objectives: To determine the efficacy, safety, and tolerability of intraarticular (IA) lorecivivint (LOR) in the treatment of knee osteoarthritis (OA).
Methods: Patients with American College of Rheumatology criteria-defined knee OA, Kellgren-Lawrence (KL) grades 2-3, and medial Joint Space Width (JSW) by radiograph between 1.5 and 4 mm in the target knee were enrolled in this phase 3, 56-week, multicentre, double-blind, placebo-controlled study.
BMJ Open
December 2024
Shanghai Shuguang Hospital Affiliated with Shanghai University of TCM, Shanghai, Shanghai, China
Introduction: Health education, weight control and exercise therapy are recognised treatment options for the non-surgical management of knee osteoarthritis (KOA); however, the pain and muscle fatigue associated with exercise make it difficult for patients to initially adhere. Traditional Chinese medicine (TCM) massage is an important complementary and alternative therapy that can effectively address these deficiencies. According to TCM theory and preliminary clinical practice, loosening of the muscles while pointing to acupoints can promote the recovery of KOA.
View Article and Find Full Text PDFKnee osteoarthritis (KOA) is a healthcare burden affecting over 595 million people worldwide. Recently, intra-articular platelet-rich plasma (PRP) injections from the patient's blood have shown promise in slowing KOA progression due to platelets' regenerative properties. This study aimed to evaluate the optimal dosing and schedule for PRP therapy in managing mild to moderate KOA.
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