This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability () values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790694 | PMC |
| http://dx.doi.org/10.1016/j.jpha.2017.05.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A cell-based model to study mechanisms of endothelial-dependent thrombin generation in response to inflammation and its modulation by hydroxychloroquine.
Res Pract Thromb Haemost
January 2025
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Background: Inflammation is a driver of thrombosis, but the phenomenon of thromboinflammation has been defined only recently, bringing together the multiple pathways involved. models can support the development of new therapeutics targeting the endothelium and also assess the existing immunomodulatory drugs, such as hydroxychloroquine, in modulating the inflammation-driven endothelial prothrombotic phenotype.
Objectives: To develop a model for thrombin generation (TG) on the surface of human endothelial cells (ECs) to assess pro/antithrombotic properties in response to inflammation.
Unraveling the Effects of Reducing and Oxidizing Pretreatments and Humidity on the Surface Chemistry of the Ru/CeO Catalyst during Propane Oxidation.
J Phys Chem C Nanomater Interfaces
January 2025
Department of Surface and Plasma Science, Faculty of Mathematics and Physics, Charles University, V Holešovičkách 2, Prague 180 00, Czechia.
This work investigates the surface chemistry of the Ru/CeO catalyst under varying pretreatment conditions and during the oxidation of propane, focusing on both dry and humid environments. Our results show that the Ru/CeO catalyst calcined in O at 500 °C initiates propane oxidation at 200 °C, achieves high conversion rates above 400 °C, and demonstrates almost no change in activity in the presence of water vapor across the entire studied temperature range of 200-500 °C. Prereduction of the oxidized Ru/CeO catalyst in H significantly enhances its activity, though this enhancement diminishes at higher temperatures.
View Article and Find Full Text PDFLaser ablation propulsion is an important micro-propulsion system for microsatellites. Polymers with carbon added and carbon-based nanomaterial have been demonstrated as propellants with high impulse coupling coefficient (C). Among them, the carbon nanotube film exhibits a low ablation threshold fluence of 25 mJ/cm, which shows its potential for propulsion under low laser fluence.
View Article and Find Full Text PDFWe report on the design of an all-mirror wavefront-division interferometer capable of spectroscopic studies across multiple spectral ranges-from the plasma frequencies of metals to terahertz wavelengths and beyond. The proposed method leverages the properties of laser sources with high spatial coherence. A theoretical framework for the interferometer scheme is presented, along with an analytical solution for determining the far-field interference pattern, which is validated through both optical propagation simulations and experimental results.
View Article and Find Full Text PDFNedosiran in pediatric patients with PH1 and relatively preserved kidney function, a phase 2 study (PHYOX8).
Pediatr Nephrol
January 2025
Novo Nordisk A/S, Lexington, MA, USA.
Background: Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder with dysregulated glyoxylate metabolism in the liver. Oxalate over-production leads to renal stones, progressive kidney damage and renal failure, with potentially life-threatening systemic oxalosis. Nedosiran is a synthetic RNA interference therapy, designed to reduce hepatic lactate dehydrogenase (LDH) to decrease oxalate burden in PH.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!