An isocratic RP-HPLC method was developed for the determination of Cefditoren pivoxil in pharmaceutical formulations using a C-18 column with water-acetonitrile (50:50, v/v) as mobile phase and flow rate 1.2 mL/min (UV detection at 218 nm). Linearity was observed in the concentration range 1.0-250 μg/mL (=0.999) with regression equation =24194+10749. The forced degradation studies were performed by using HCl, NaOH, and HO, and thermal and UV radiation. Cefditoren pivoxil is more sensitive towards oxidation and alkaline conditions and resistant towards acidic and photolytic degradations. The method was validated as per ICH guidelines.
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| http://dx.doi.org/10.1016/j.jpha.2012.06.003 | DOI Listing |
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Article Synopsis
- Cefditoren is an oral cephalosporin antibiotic showing strong activity against Streptococcus pneumoniae, but its pharmacokinetics and pharmacodynamics (PK/PD) are not well understood; this study aimed to fill that gap using a mouse model of lung infection.
- The research involved in vitro susceptibility testing and time-kill assays to evaluate cefditoren's effectiveness against S. pneumoniae, leading to calculations of optimal PK/PD parameters needed to reduce bacterial counts significantly.
- Results indicated cefditoren is effective in treating pneumonia caused by S. pneumoniae, achieving significant bacterial kill at specific PK/PD ratios, with recommended dosing showing a minimum inhibitory concentration (MIC) of
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