The present study was aimed at the comparison of the pharmacokinetics of pure chlorogenic acid and extract of Thunb. The animals were allocated to two groups, and were administered chlorogenic acid or extract of Thunb. at a dose of 50.0 mg/kg orally. Blood samples were collected up to 8 h post-dosing. Plasma chlorogenic acid analyses were performed using an HPLC method with UV detector. The pharmacokinetic parameters were evaluated using non-compartmental assessment. Significant differences existed in the two groups for AUC , AUC and CLz/F. The reliable HPLC method was successfully applied to the determination of chlorogenic acid in rat plasma at dosage of 50.0 mg/kg.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760807 | PMC |
| http://dx.doi.org/10.1016/j.jpha.2011.09.006 | DOI Listing |
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