Two new secondary metabolites from a fungus of the genus Robillarda.

J Antibiot (Tokyo)

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.

Published: March 2018

Two new compounds, robillafuran and (+)-robillapyrone, were isolated from the culture extract of a fungal strain of Robillarda along with (+)-monascuspyrone. The absolute configuration of (+)-robillapyrone and (+)-monascuspyrone was determined by ECD calculation. These three compounds showed preadipocyte differentiation activity at 10-40 μM.

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http://dx.doi.org/10.1038/s41429-017-0015-xDOI Listing

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