Two new compounds, robillafuran and (+)-robillapyrone, were isolated from the culture extract of a fungal strain of Robillarda along with (+)-monascuspyrone. The absolute configuration of (+)-robillapyrone and (+)-monascuspyrone was determined by ECD calculation. These three compounds showed preadipocyte differentiation activity at 10-40 μM.
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http://dx.doi.org/10.1038/s41429-017-0015-x | DOI Listing |
BMC Genomics
January 2025
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
The E. coli strains harboring the polyketide synthase (pks) island encode the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer. The present study involves whole-genome-wide comparison and phylogenetic analysis of pks harboring E.
View Article and Find Full Text PDFNat Microbiol
January 2025
Department of Chemistry, Indiana University, Bloomington, IN, USA.
To overtake competitors, microbes produce and secrete secondary metabolites that kill neighbouring cells and sequester nutrients. This metabolite-mediated competition probably evolved in complex microbial communities in the presence of viral pathogens. We therefore hypothesized that microbes secrete natural products that make competitors sensitive to phage infection.
View Article and Find Full Text PDFSci Rep
January 2025
School of Pharmacy, Chengdu University of TCM, Chengdu, 611137, China.
Habitat requirements and species' ecological suitability are essential conditions for species conservation and management. Under the influence of different environmental variables, assessing the habitat quality of medicinal plants is an important issue to ensure the quality of medicinal plants and protect biodiversity. This study explores the impact of environmental variables on the distribution of Astragalus mongholicus Bunge (A.
View Article and Find Full Text PDFAnticancer Agents Med Chem
January 2025
Department of Biotechnology, Jamia Hamdard, New Delhi, 110062, India.
This review investigates the outcome of heavy metal contamination on the anti-cancer properties of medicinal plants. Heavy metal pollution is a significant environmental concern globally, often found in soil and water due to industrial activities. Therapeutic plants are recognized because of their therapeutic attributes and their ability to absorbing these contaminants.
View Article and Find Full Text PDFCurr Pharm Des
January 2025
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
Introduction: This study aims to isolate and characterize potential cytotoxic compounds from the roots of Bauhinia variegata Linn. (Caesalpiniaceae) and evaluate their activity against human cancer cell lines. Five compounds, namely β-sitosterol (1), piperine (2), piperolein B (3), retrofractamide A (4), and dehydropipernonaline (5), were isolated from B.
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