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Human plasma cells engineered to secrete bispecifics drive effective in vivo leukemia killing.
Mol Ther
August 2024
Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA; University of Washington, Departments of Pediatrics and Pharmacology, Seattle, WA, USA. Electronic address:
Bispecific antibodies are an important tool for the management and treatment of acute leukemias. As a next step toward clinical translation of engineered plasma cells, we describe approaches for secretion of bispecific antibodies by human plasma cells. We show that human plasma cells expressing either fragment crystallizable domain-deficient anti-CD19 × anti-CD3 (blinatumomab) or anti-CD33 × anti-CD3 bispecific antibodies mediate T cell activation and direct T cell killing of B acute lymphoblastic leukemia or acute myeloid leukemia cell lines in vitro.
View Article and Find Full Text PDFHuman plasma cells engineered to secrete bispecifics drive effective leukemia killing.
bioRxiv
August 2023
Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle WA.
Bispecific antibodies are an important tool for the management and treatment of acute leukemias. Advances in genome-engineering have enabled the generation of human plasma cells that secrete therapeutic proteins and are capable of long-term engraftment in humanized mouse models. As a next step towards clinical translation of engineered plasma cells (ePCs) towards cancer therapy, here we describe approaches for the expression and secretion of bispecific antibodies by human plasma cells.
View Article and Find Full Text PDFExperiences and priorities of older adults during the COVID-19 pandemic.
Ir J Med Sci
October 2022
Age-Related Health Care Department, Tallaght University Hospital, Dublin, Ireland.
Background: Throughout the COVID-19 pandemic, older adults have been prioritized in public health campaigns to limit social interactions and 'cocoon' in their homes. This limits the autonomy of older people and may have unintended adverse consequences.
Aims: To ascertain the self-reported physical and psychological effects of 'cocooning' and the expressed priorities of older adults themselves during the pandemic.
Patients' and Clinicians' Perceptions of Clinician-Expressed Empathy in Advanced Cancer Consultations and Associations with Patient Outcomes.
Palliat Med Rep
June 2020
Health, Medical and Neuropsychology Unit, Institute of Psychology, Leiden University, Leiden, The Netherlands.
Article Synopsis
- Empathy is essential for effective communication in healthcare, but there is a disconnect between how patients and clinicians perceive the empathy expressed by clinicians during advanced cancer consultations.
- A study involving 41 consultations found that patients rated clinician-expressed empathy significantly higher than clinicians did, and patient perceptions of empathy were linked to better anxiety management, greater satisfaction, and lower emotional distress.
- The lack of correlation between clinicians' perceptions and patient outcomes suggests that clinicians should be more attuned to how their empathy is perceived by patients to enhance patient care.
Addressing General Surgery Residents' Concerns in the Early Phase of the COVID-19 Pandemic.
J Surg Educ
July 2020
Department of Surgery, Veterans Affairs Boston Healthcare System, Boston, Massachusetts; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
Objective: The purpose of this study was to determine the concerns of General Surgery residents as they prepare to be in the frontlines of the response against coronavirus disease 2019 (COVID-19_).
Design, Setting, And Participants: A qualitative study with voluntary dyadic and focus group interviews with a total of 30 General Surgery residents enrolled at 2 academic medical centers in Boston, Massachusetts was conducted between March 12 to 16, 2020.
Results: The most commonly reported personal concern related to the COVID-19 outbreak was the health of their family (30 of 30 [100%]), followed by the risk of their transmitting COVID-19 infection to their family members (24 of 30 [80%]); risk of their transmitting COVID-19 infection their patients (19 of 30 [63%]); anticipated overwork for taking care of a high number of patients (15 of 30 [50%]); and risk of their acquiring COVID-19 infection from their patients (8 of 30 [27%]) .
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