Objectives: The objective is to establish an approximate relative fatigue life estimation method under simulated mastication load for thin-walled monolithic restorations.
Methods: Experimentally measured fatigue parameters of fluormica, leucite, lithium disilicate and yttrium-stabilized zirconia in the existing literature were expressed in terms of the maximum cyclic stress and stress corresponding to initial crack size prior to N number of loading cycles to assess their differences. Assuming that failures mostly originate from high stress region, an approximate restoration life method was explored by ignoring the multi-axial nature of stress state. Experiments utilizing a simple trilayer restoration model with ceramic LD were performed to test the model validity.
Results: Ceramic fatigue was found to be similar for clinically relevant loading range and mastication frequency, resulting in the development of an approximate fatigue equation that is universally applicable to a wide range of dental ceramic materials. The equation was incorporated into the approximate restoration life estimation, leading to a simple expression in terms of fast fracture parameters, high stress area ΔA, the high stress averaged over ΔA and N. The developed method was preliminarily verified by the experiments. The impact of fast fracture parameters on the restoration life was separated from other factors, and the importance of surface preparation was manifested in the simplified equation. Both the maximum stress and the area of high stress region were also shown to play critical roles.
Significance: While nothing can replace actual clinical studies, this method could provide a reasonable preliminary estimation of relative restoration life.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904010 | PMC |
http://dx.doi.org/10.1016/j.dental.2018.01.020 | DOI Listing |
Alzheimers Dement
December 2024
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, NSW, Australia.
Background: Alzheimer's Disease (AD) poses a substantial global health burden, necessitating innovative therapeutic strategies. This study investigates the neuroprotective potential of a chrysin-loaded Nanostructured Lipid Carrier (NLC) drug delivery system in AD management. Employing the high-pressure homogenization method, chrysin-loaded NLCs were meticulously formulated to optimize drug delivery efficiency.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, NSW, Australia.
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the impairment of cognitive development and disruption of neurocognitive function. This neuropathological condition is marked by neurodegeneration, loss of neural tissue, and the formation of neurofibrillary tangles and Aβ plaques. Various studies reported the utilization of phytoconstituents like fisetin, quercetin, berberine, and xanthohumol for the treatment of AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, India.
Background: Alzheimer's disease (AD) is a type of degenerative disorder that affects the brain. There are various herbal drugs that have been tested for their effectiveness in treating AD, and chrysin is one of them. Chrysin is a polyphenolic flavonoid that has several neuroprotective effects, including reducing the levels of AChE enzyme, accumulated amyloid β, oxidative stress, and neuroinflammation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Background: Alzheimer's disease (AD) is a progressive and multifactorial neurodegenerative disease that still has no cure. Different pathological processes contribute to the disease's development, such as the presence of amyloid beta (Aβ) plaques, neurofibrillary tangles (NFTs), glutamatergic excitotoxicity, oxidative stress, and neuroinflammation. Chalcones are polyphenolic compounds of natural origin with a wide range of biological activities, and emerging studies have reported neurotrophic activity, anti-inflammatory and antioxidant effects, and the inhibition of Aβ aggregation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE) Rostock/Greifswald, Rostock, Germany.
Background: Using artificial intelligence approaches enable automated assessment and analysis of speech biomarkers for Alzheimer's disease, for example using chatbot technology. However, current chatbots often are unsuitable for people with cognitive impairment. Here, we implemented a user-centred-design approach to evaluate and improve usability of a chatbot system for automated speech assessments for people with preclinical, prodromal and early dementia.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!