Numerous studies have examined the influence of rainfall on the relative risk of crash, and they all agree that rainfall leads to an increase in relative risk as compared to dry conditions; what they do not agree on is the magnitude of these increases. Here we consider three methodological decisions made in computing the relative risk and examine their impacts: the inclusion or exclusion of zero total events (where no crashes occur during event or control periods), the temporal scale of analysis, and the use of information on pavement and weather conditions contained with the crash reports to determine relative risk. Our analyses are based on several years of data from six U.S. states (Arkansas, Georgia, Illinois, Maryland, Minnesota and Ohio). Zero total events in the context of weather related crash studies typically provide no information on the actual crash odds and greatly alter the distribution of relative risk estimates and should be removed from the analysis. While the use of a daily time step provides an estimate of relative risk that is not significantly different from an hourly time step for the majority of rural counties in our study area, the same is true of only 39% of the urban counties. Finally, the use of pavement and weather condition information from the crash reports results in relative risk estimates that are lower than the standard approach, however this difference decreases as rainfall totals increase. By highlighting the influence of methodological choices, we hope to pave the way towards the potential reduction in uncertainties in weather-related relative risk estimates.
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http://dx.doi.org/10.1016/j.aap.2018.01.023 | DOI Listing |
Genet Med
December 2024
Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN; Center for Digital Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN. Electronic address:
Purpose: The value of genetic information for improving the performance of clinical risk prediction models has yielded variable conclusions. Many methodological decisions have the potential to contribute to differential results. We performed multiple modeling experiments integrating clinical and demographic data from electronic health records (EHR) with genetic data to understand which decisions may affect performance.
View Article and Find Full Text PDFJ Eval Clin Pract
February 2025
College of Medicine, University of Central Florida, Orlando, Florida, USA.
Aims And Objectives: Approximately 50% of Americans report having low health insurance literacy, leading to uncertainty when choosing their insurance coverage to best meet their healthcare needs. Therefore, we aimed to evaluate the association between lack of prescription drug benefit knowledge and problems paying medical bills among Medicare beneficiaries.
Methods: We analysed the 2021 Medicare Current Beneficiary Survey Public Use File of 5586 Medicare beneficiaries aged ≥ 65 years.
J Eval Clin Pract
February 2025
Initiative for Slow Medicine, Berkeley, California, USA.
Appropriate patient reassurance is an essential feature of clinical practice. My recent experience as a patient, interpreted via my expertise as a health services researcher, led me to insights on ideal and suboptimal reassurance styles in the context of worrisome symptoms. Reassurance is complex: often poorly defined in the scientific literature, rarely rigorously studied, imperfectly understood, and requiring some adaptation to each patient situation.
View Article and Find Full Text PDFAm J Case Rep
December 2024
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
BACKGROUND Limb-girdle muscular dystrophy recessive 1 (LGMDR1) is an autosomal recessive degenerative muscle disorder characterized by progressive muscular weakness caused by pathogenic variants in the CAPN3 gene. Desmoplastic small round cell tumors (DSRCT) are ultra-rare and aggressive soft tissue sarcomas usually in the abdominal cavity, molecularly characterized by the presence of a EWSR1::WT1 fusion transcript. Mouse models of muscular dystrophy, including LGMDR1, present an increased risk of soft tissue sarcomas.
View Article and Find Full Text PDFMed Sci Monit
December 2024
Department of Neurology, HangZhou Third People's Hospital, Hangzhou, Zhejiang, China.
BACKGROUND This study aimed to analyze the risk factors of central nervous system (CNS) infection caused by reactivation of varicella zoster virus (VZV) and provide reference for the prevention and early diagnosis of VZV-associated CNS infection. MATERIAL AND METHODS A prospective study was conducted on 1030 patients with acute herpes zoster (HZ) admitted to our hospital from January 2021 to June 2023. According to clinical manifestations and auxiliary examinations, they were divided into HZ group of 990 patients and VZV-associated CNS infection group of 40 patients.
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