The isolation and characterization from the sand fly of a yeast strain (1F1) displaying the killer phenotype was recently reported. In the present work, the killer toxin (KT) produced by 1F1 was purified and characterized, and its antimicrobial activity in vitro was investigated against fluconazole- susceptible and -resistant clinical isolates and laboratory strains of and displaying known mutations. 1F1-KT showed a differential killing ability against different mutant strains of the same species. The results may be useful for the design of therapeutic molecules based on 1F1-KT and the study of yeast resistance mechanisms.
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| http://dx.doi.org/10.3390/toxins10020068 | DOI Listing |
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