β-catenin acts as a key mediator of Wnt signaling by migrating into the nucleus. In this issue of Developmental Cell, Griffin et al. (2018) propose that facilitated nuclear import of β-catenin is actively regulated by the nuclear small GTPase Rap through its guanine nucleotide exchange factor, RAPGEF5.
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| http://dx.doi.org/10.1016/j.devcel.2018.01.004 | DOI Listing |
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