The evolution and diversification of bacterial pathogens within human hosts represent potential barriers to the diagnosis and treatment of life-threatening infections. Tremendous genetic and phenotypic diversity is characteristic of host adaptation in strains of Pseudomonas aeruginosa that infect the airways of individuals with chronic lung diseases and prove to be extremely difficult to eradicate. In this MiniReview, we examine recent advances in understanding within-host diversity and antimicrobial resistance in P. aeruginosa populations from the lower airways of individuals with the fatal genetic disease cystic fibrosis and the potential impacts that this diversity may have on detecting and interpreting antimicrobial susceptibility within these populations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/femsle/fny026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluating the microgap and sealing capability in four implant systems with different interlockings under different tightening torques: an study.
J Adv Prosthodont
December 2024
Department Prosthetic Dental Sciences, College of Dentistry, Jouf University, Jouf, Saudia Arabia.
Purpose: This study assessed the microgap width and adhesion of three bacterial species in four dental implants with different interlocks under four screwing torques.
Materials And Methods: Ten samples of four implant systems with various interlockings, including full-hexagonal (FHI), cylindrical-conical trilobe-index (TLI), Morse-taper with octagon terminal index (OI), and hexagonal interlock (slip-fit) (HI-SF), were used. The abutments were screwed to the fixtures under torques of 10, 20, 30, and 40 Ncm.
Respiratory Protective Effects of Perilla Leave Varieties () Against Fine Particulate Matter (PM)-induced Damage in Human Nasal Cells.
Food Sci Nutr
January 2025
Department of Southern Area Crop Science National Institute of Crop Science, Rural Development Administration Milyang Korea.
Fine particulate matter (PM2.5) is known to exacerbate chronic respiratory disorders, primarily by inducing inflammatory responses and mucus overproduction. Perilla leaves are reported to have significant health benefits, such as antioxidant, antibacterial, and antiallergic properties, attributed to phenolic compounds that vary depending on genetic diversity.
View Article and Find Full Text PDFChronic inflammation and heme-iron overload can result from bacterial hemolysis. Along with the synthetic drugs, numerous traditional and functional food approaches are equally trialed to eradicate the problem. As a prospective new source of dietary protein hydrolysates, freshwater mollusks () have recently drawn huge interest from researchers.
View Article and Find Full Text PDFStudy on the Mobile Colistin Resistance (mcr-1) Gene in Gram-Negative Bacilli in a Rural Tertiary Care Hospital in Western Maharashtra.
Cureus
December 2024
Department of Microbiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth, Karad, IND.
Background: Colistin, a last-resort antibiotic for treating multidrug-resistant Gram-negative bacterial infections, has increased resistance as a result of the emergence of the gene. The 1gene, which confers colistin resistance, is often carried on plasmids, facilitating its spread by horizontal gene transfer among bacterial populations. The rising prevalence of 1mediated resistance poses significant challenges for infection control and treatment efficacy.
View Article and Find Full Text PDFPrognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy.
Front Microbiol
December 2024
Department of Emergency, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Objectives: Sepsis-associated encephalopathy (SAE) has a high incidence and mortality, especially for elderly patients and patients who are positive for pathogenic microbial infection, this study explored the prognostic factors influencing the prognosis of elderly patients with pathogenic microorganisms positive of sepsis-associated encephalopathy.
Methods: Patients with SAE and pathogenic microbiology positive were included in this study from Medical Information Mart for Intensive Care IV (MIMIC IV) database. The main results of this study was analyzed the 28-day mortality rate of patients with pathogenic microorganism positive and SAE by Wilcoxon, Kaplan-Meier curve and other methods.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!