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Human erythrocyte lifespan measured by Levitt's CO breath test with newly developed automatic instrument. | LitMetric

Human erythrocyte lifespan measured by Levitt's CO breath test with newly developed automatic instrument.

J Breath Res

Institute of Breath Test Research, Shenzhen University, Shenzhen, People's Republic of China. Department of Gastroenterology, Nanshan Hospital, Guangdong Medical University, Shenzhen, People's Republic of China.

Published: March 2018

AI Article Synopsis

  • Current methods for measuring RBC lifespan, such as using isotopes, are complicated and take a lot of time.
  • Levitt's CO breath test, tested on 200 subjects, shows that healthy individuals have an average RBC lifespan of 126 days, consistent with traditional methods, while those with chronic hemolytic anemia have significantly shorter lifespans averaging 29 days.
  • The study confirms that Levitt's CO breath test is an effective and convenient way to measure RBC lifespan, making it useful for clinical applications.

Article Abstract

Existing standard techniques for erythrocyte (RBC) lifespan measurement, such as quantitation of labeling with isotopes or biotin, are cumbersome and time-consuming. Given that endogenous CO originates mainly from degraded RBCs, a team lead by Levitt developed a CO breath test to enable more efficient RBC lifespan estimation. The purpose of this study was to evaluate the reliability of Levitt's CO breath test method with our newly developed automatic instrument. RBC lifespan measurements conducted by Levitt's CO breath test method were conducted in 109 healthy subjects and 91 patients with chronic hemolytic anemia. In healthy subjects, the RBC lifespan was 126 ± 26 days, similar to values obtained with classical standard labeling methods. RBC lifespan did not differ significantly between males and females or between juveniles and adults, and did not correlate with age. To our knowledge, this datum represents an RBC lifespan average for the largest sample to date. In subjects with hemolytic anemia, RBC lifespan was 29 ± 14 days, which is significantly shorter than that of the healthy subjects (p = 0.001). Using 75 days as a cut-off, diagnostic accuracy for hemolytic anemia in the present study sample was 100%. In conclusion, the present results indicate that Levitt's CO breath test is an ideal method for human RBC lifespan measurement, and the newly developed automatic instrument is reliable and convenient for clinical practice.

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Source
http://dx.doi.org/10.1088/1752-7163/aaacf1DOI Listing

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