Artificial synaptic devices that mimic the functions of biological synapses have drawn enormous interest because of their potential in developing brain-inspired computing. Current studies are focusing on memristive devices in which the change of the conductance state is used to emulate synaptic behaviors. Here, a new type of artificial synaptic devices based on the memtranstor is demonstrated, which is a fundamental circuit memelement in addition to the memristor, memcapacitor, and meminductor. The state of transtance (presented by the magnetoelectric voltage) in memtranstors acting as the synaptic weight can be tuned continuously with a large number of nonvolatile levels by engineering the applied voltage pulses. Synaptic behaviors including the long-term potentiation, long-term depression, and spiking-time-dependent plasticity are implemented in memtranstors made of Ni/0.7Pb(Mg Nb )O -0.3PbTiO /Ni multiferroic heterostructures. Simulations reveal the capability of pattern learning in a memtranstor network. The work elucidates the promise of memtranstors as artificial synaptic devices with low energy consumption.
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http://dx.doi.org/10.1002/adma.201706717 | DOI Listing |
Alzheimers Dement
December 2024
Cleveland Clinic, Cleveland, OH, USA.
Background: Microglia have been implicated as a key aspect of the pathology of Alzheimer's disease (AD). However, high microglial heterogeneities, including disease-associated microglia (DAM), tau microglia (tau-pathology related), and neuroinflammation-like microglia (NIM), hinder the development of microglia-targeted treatment.
Method: In this study, we integrated ∼0.
Alzheimers Dement
December 2024
Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Adenosine receptor 1 (A1R) is the predominant subtype of adenosine receptors, primarily distributed in memory-associated brain regions such as the cortex, hippocampus, and cerebellum. It actively participates in plasticity-regulated synaptic transmission and is crucial for functions related to sleep, arousal, cognition, learning, and memory. In a recent study, we reported that an elevation in A1R signaling mediates aberrant neuron-glial crosstalk in Alzheimer's disease.
View Article and Find Full Text PDFAdv Mater
January 2025
School of Electronic and Computer Engineering, Peking University, Shenzhen, 518055, China.
The increasing demand for mobile artificial intelligence applications has elevated edge computing to a prominent research area. Silicon materials, renowned for their excellent electrical properties, are extensively utilized in traditional electronic devices. However, the development of silicon materials for flexible neuromorphic computing devices encounters great challenges.
View Article and Find Full Text PDFNat Commun
January 2025
School of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.
Biological neural circuits demonstrate exceptional adaptability to diverse tasks by dynamically adjusting neural connections to efficiently process information. However, current two-dimension materials-based neuromorphic hardware mainly focuses on specific devices to individually mimic artificial synapse or heterosynapse or soma and encoding the inner neural states to realize corresponding mock object function. Recent advancements suggest that integrating multiple two-dimension material devices to realize brain-like functions including the inter-mutual connecting assembly engineering has become a new research trend.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea.
Neuroprosthetics equipped with artificial synapses hold promise to address some most intricate medical problems, such as human sensory disorders. Yet, it is necessitated and of paramount importance for neuroprosthetics to be able to differentiate significant and insignificant signals. Here, we present an information-filterable artificial retina system that integrates artificial synapses with a signal-integration device for signal perception and processing with attention.
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