Psychotropic medications are often prescribed to reduce challenging behavior in individuals with intellectual and developmental disabilities (IDD). Functional analyses (FAs) have demonstrated utility in assessing medication impact on behavior; however, the impact of adverse side effects (ASE) on challenging behavior is under-assessed. The purpose of this study was to develop a methodology, similar to FAs, to explore potential medication ASE impact on challenging behavior in seven individuals with IDD. Results revealed response rate differences in designed ASE conditions for most participants. Outcomes support further development and use of this methodology to assess the presence and impact of ASEs.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791745 | PMC |
http://dx.doi.org/10.1007/s10882-017-9570-0 | DOI Listing |
Sci Rep
December 2024
School of Electrical Engineering, Vellore Institute of Technology, Chennai, 600127, India.
Spherical tanks have been predominantly used in process industries due to their large storage capability. The fundamental challenges in process industries require a very efficient controller to control the various process parameters owing to their nonlinear behavior. The current research work in this paper aims to propose the Approximate Generalized Time Moments (AGTM) optimization technique for designing Fractional-Order PI (FOPI) and Fractional-Order PID (FOPID) controllers for the nonlinear Single Spherical Tank Liquid Level System (SSTLLS).
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December 2024
Computer Science Department, Saarland University, Saarbrücken, Germany.
Estimating the numbers and whereabouts of internally displaced people (IDP) is paramount to providing targeted humanitarian assistance. In conflict settings like the ongoing Russia-Ukraine war, on-the-ground data collection is nevertheless often inadequate to provide accurate and timely information. Satellite imagery may sidestep some of these challenges and enhance our understanding of the IDP dynamics.
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December 2024
Department of Neuroscience and Padova Neuroscience Center, Università di Padova, Padova, Italy.
Can focal brain lesions, such as those caused by stroke, disrupt critical brain dynamics? What biological mechanisms drive its recovery? In a recent study, we showed that focal lesions generate a sub-critical state that recovers over time in parallel with behavior (Rocha et al., Nat. Commun.
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December 2024
Laboratorio de Fluidodinámica, Facultad de Ingeniería, Universidad de Buenos Aires/CONICET, Paseo Colón 850 CABA, Buenos Aires, Argentina.
The oil and gas industry faces two significant challenges, including rising global temperatures and depletion of reserves. Enhanced recovery techniques such as polymer flooding have positioned themselves as an alternative that attracts international attention thanks to increased recovery factors with low emissions. However, existing physical models need further refinement to improve predictive accuracy and prevent design failures in polymer flooding projects.
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December 2024
Department of Pharmacology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Medicine, Southeast University, Nanjing, China.
While circular RNAs (circRNAs) exhibit lower abundance compared to corresponding linear RNAs, they demonstrate potent biological functions. Nevertheless, challenges arise from the low concentration and distinctive structural features of circRNAs, rendering existing methods operationally intricate and less sensitive. Here, we engineer an intelligent tetrahedral DNA framework (TDF) possessing precise spatial pattern-recognition properties with exceptional sensing speed and sensitivity for circRNAs.
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