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| http://dx.doi.org/10.1007/s12288-017-0834-8 | DOI Listing |
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Paclitaxel improves thrombopoiesis in the absence of thrombopoietin receptor (Mpl).
J Thromb Haemost
December 2024
The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, China. Electronic address:
Background: Platelets are critical for thrombosis and hemostasis. The THPO-MPL pathway is the primary pathway for generating thrombocytes. Dysregulation of thrombopoiesis results in platelet formation and/or function-related disorders, such as thrombocytopenia.
View Article and Find Full Text PDFProteomic screening identifies PF4/Cxcl4 as a critical driver of myelofibrosis.
Leukemia
September 2024
Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Despite increased understanding of the genomic landscape of Myeloproliferative Neoplasms (MPNs), the pathological mechanisms underlying abnormal megakaryocyte (Mk)-stromal crosstalk and fibrotic progression in MPNs remain unclear. We conducted mass spectrometry-based proteomics on mice with Romiplostim-dependent myelofibrosis to reveal alterations in signaling pathways and protein changes in Mks, platelets, and bone marrow (BM) cells. The chemokine Platelet Factor 4 (PF4)/Cxcl4 was up-regulated in all proteomes and increased in plasma and BM fluids of fibrotic mice.
View Article and Find Full Text PDFPlasmacytoid dendritic cells control homeostasis of megakaryopoiesis.
Nature
July 2024
Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.
Article Synopsis
- Platelet homeostasis is vital for blood vessel stability and immune response, but the mechanisms behind the replenishment of their precursor cells (megakaryocytes) are not well understood.
- Researchers used intravital imaging to discover that plasmacytoid dendritic cells (pDCs) act as sensors in the bone marrow that detect dying megakaryocytes and stimulate the proliferation of their progenitor cells through the release of IFNα.
- The study highlights that while pDCs usually help fight viral infections, their activation by viruses like SARS-CoV-2 disrupts their monitoring function, leading to an overproduction of megakaryocytes.
Transient Acquired Amegakaryocytic Thrombocytopenia in the Setting of Severe Sepsis: A Case Report.
Cureus
July 2024
Hematology and Oncology, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Acquired amegakaryocytic thrombocytopenia (AATP) is a rare disorder in which severely low platelet levels occur due to reduced or complete absence of megakaryocytes in the bone marrow. The pathophysiology of this disease is not fully understood, although anti-thyroid peroxidase antibodies (anti-TPO) binding to cellular-myeloproliferative leukemia (c-mpl) receptors is a proposed mechanism. Currently, no standard published guideline for treatment exists, but immunosuppressive therapies have been used based on the proposed mechanism and associated conditions.
View Article and Find Full Text PDFMixed-phenotype acute leukemia, T/megakaryoblastic: does it really exist?
J Hematop
March 2023
Department of Hematology & Blood Center, Indus Hospital & Health Network, Korangi Campus Plot C-76, Sector 31/5, Opposite Darussalam Society Korangi Crossing, Karachi, Pakistan.
Mixed-phenotype acute leukemias (MPAL) account for < 4% of all cases of acute leukemias. These are a heterogeneous group of leukemias grouped together by the WHO classification as "rare subtypes." The diagnosis and treatment of MPAL is extremely challenging particularly for low middle income countries.
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