A domino reaction sequence has been evaluated that begins with union of novel dihydrooxazinone precursors with 2-alkynyl-substituted benzaldehyde components through aldol condensation. Ensuing operations, including alkene isomerization, Diels-Alder, and retrograde Diels-Alder with loss of CO occurs in the same reaction vessel to provide polysubstituted tricyclic pyridine products.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791744 | PMC |
| http://dx.doi.org/10.1055/s-0036-1588729 | DOI Listing |
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